BILL ANALYSIS                                                                                                                                                                                                    






                                 SENATE HEALTH
                               COMMITTEE ANALYSIS
                         Senator Sheila J. Kuehl, Chair


          BILL NO:                  AB 501                            
          A
          AUTHOR:                 Swanson                             
          B
          AMENDED:              May 6, 2008                          
          HEARING DATE:    June 11, 2008                              
          5
          FISCAL:        Keyed Nonfiscal                              
          0              
          CONSULTANT:                                                 
          1
          Hansel/sh                                                  
                                        

                                     SUBJECT
                                         
                             Pharmaceutical devices

                                     SUMMARY  

          Requires pharmaceutical manufacturers, upon request, to  
          arrange to provide consumers who are prescribed pre-filled  
          syringes, pre-filled pens, or other pre-filled injection  
          devices, with a postage prepaid mail-back sharps container,  
          or other approved sharps container.  Requires such  
          manufacturers to also provide information on safe disposal  
          alternatives and options for sharps.


                             CHANGES TO EXISTING LAW  

          Existing law:
          Existing law, the Medical Waste Management Act (Act),  
          establishes a comprehensive regulatory system for the  
          generation, handling, storage, transport, treatment, and  
          disposal of medical waste, as defined, which is overseen by  
          the Department of Public Health (DPH) and designated local  
          agencies.

          Existing law allows DPH to approve home-generated sharps  
          waste consolidation locations, to which persons may  
                                                         Continued---



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          transport home-generated sharps waste, and also allows  
          medical facilities which generate and handle medical waste  
          to collect such waste.  Existing law additionally allows  
          city and county household hazardous waste plans to include  
          programs for the safe collection, treatment, and disposal  
          of home-generated sharps waste, as specified.

          Effective September 1, 2008, existing law prohibits a  
          person from knowingly placing home-generated sharps waste  
          in any container used for the commercial and residential  
          collection of solid waste, recyclable materials, or green  
          waste.  Existing law also provides that, after September 1,  
          2008, home-generated sharps waste may only be transported  
          in sharps containers, as defined, or other containers that  
          are approved by DPH or a local enforcement agency, and may  
          only be managed at a household hazardous waste facility, as  
          defined, a home-generated sharps consolidation point, as  
          defined, a medical waste generator's facility, or a waste  
          treatment facility through the use of an approved medical  
          waste mail-back container, as specified.  "Home-generated  
          sharps waste" is defined in existing law as hypodermic  
          needles, pen needles, intravenous needles, lancets, and  
          other devices that are used to penetrate the skin for the  
          delivery of medications, that are derived from a household,  
          including a multifamily residence or household.  
          
          This bill:
          This bill would require pharmaceutical manufacturers, upon  
          request, to provide consumers who are prescribed pre-filled  
          syringes, pre-filled pens, or other pre-filled injection  
          devices, with either a postage prepaid mail-back sharps  
          container that has been approved by the U.S. Postal Service  
          and DPH, or an approved sharps container that will  
          facilitate the safe storage of the sharps waste, and safe  
          transport to a sharps consolidation location that is  
          approved by DPH, or to a clinic, physician, or pharmacy  
          that accepts home-generated sharps waste.  The manufacturer  
          would also be required to provide information on safe  
          disposal alternatives and options for sharps.
          

                                  FISCAL IMPACT  

          According to the Assembly Floor analysis, this bill would  
          have no direct fiscal impact.




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                            BACKGROUND AND DISCUSSION  

          According to the author, the unsafe disposal of needles and  
          syringes into non-medical waste management systems is a  
          major and unnecessary public health risk.  The author  
          states that AB 501 will make it easier for patients who use  
          self-injection devices for the treatment of conditions such  
          as diabetes, hepatitis, HIV, arthritis, allergies, and  
          multiple sclerosis, to safely and efficiently dispose of  
          their used sharps, by requiring pharmaceutical  
          manufacturers to provide a means for patients to receive  
          either a postage prepaid mail-back container or other  
          approved container for the sharps.  The author cites  
          statistics indicating that at least two billion lawful  
          injections of medications occur yearly outside of health  
          care settings in California.  Most of these used needles  
          end up in household trash and pose a significant risk of  
          injury and/or infection to children, sanitation workers,  
          and solid waste collection employees.  The author states  
          that the Legislature has already authorized sharps  
          mail-back programs, utilizing containers and packaging  
          approved by the postal service, as a means of collecting  
          and destroying home-generated sharps, and has made previous  
          findings and declarations that the cooperative efforts of  
          the pharmaceutical industry are needed as part of the  
          development of a safe needle disposal system for  
          California.  

          Pre-filled syringes, pens and self- injection devices
          Pre-filled syringes and pen injectors were developed,  
          beginning in the 1980s, for the reliable and accurate  
          injection at home of medications that must be taken  
          frequently.  While use of the devices was initially limited  
          to insulin and human growth hormone, applications have more  
          recently been developed for drugs used to treat multiple  
          sclerosis, cancer, and infertility, as well as hormone  
          replacement drugs, blood factors, and vaccines.  Use of the  
          devices has, in part, been accelerated by efforts made by  
          managed care plans to control costs by eliminating, for  
          certain medications, the use of a health care professional  
          to administer the medication.  Pre-filled syringes can be  
          used directly, or in conjunction with various  
          auto-injectors, which automatically insert the needle and  
          administer the injection, by means of a spring-loaded  




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          device.  Pen injectors are cartridge devices that  
          accommodate a single or multiple doses of a medication.   
          Many patients find these devices to be a more user-friendly  
          means of administering injection medications than standard  
          syringes.  In the case of multiple-dose pen injectors, the  
          patient must remove and dispose of the needle upon  
          completion of the injection.  

          The Medical Waste Management Act
          The Medical Waste Management Act, which became effective in  
          1991, and which is administered by DPH and designated local  
          entities, establishes a comprehensive system for regulating  
          the collection, transport, and treatment of medical waste.   
          The Act provides for the registration of medical waste  
          generators and transporters, requires operating permits for  
          treatment facilities such as incinerators and steam  
          sterilization units, and specifies methods for storing  
          medical waste and treating it so it may be handled as solid  
          waste.  In 1995 the Act was amended to recognize  
          home-generated sharps waste as a type of medical waste and  
          to establish consolidation points for such waste, including  
          at health care facilities.  Further amendments in 2004  
          allowed city and county household hazardous waste programs  
          to accept home-generated sharps waste.  SB 1305 (Figueroa)  
          of 2006 amended the Act to prohibit, effective September 1,  
          2008, persons from knowingly placing home-generated sharps  
          waste in residential or commercial waste stream containers,  
          and to require these wastes to be transported in sharps  
          containers to approved medical waste collection sites or  
          household hazardous waste facilities, or to be sent to  
          approved medical waste treatment facilities through  
          approved mail-back systems.  

          Producer responsibility initiatives
          A number of environmental organizations are promoting  
          initiatives to encourage producers and distributors of  
          certain products, particularly those requiring special  
          handling such as batteries, paints, electronic components,  
          and medical devices, to shoulder greater responsibility for  
          the proper disposal of the products.  A number of  
          organizations support the concept of "Extended Producer  
          Responsibility" (EPR), which encompasses incentives and  
          mandates to make producers, and other entities which handle  
          their products, responsible for the disposal and management  
          of the products, and to encourage producers to make changes  




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          to their products to minimize their impact on human health  
          and the environment.  The California Integrated Waste  
          Management Board recently developed a policy framework  
          intended to guide proposals to promote EPR.

          Prior legislation:
          SB 372 (Wright), Chapter 877, Statues of 1995, amended the  
          Medical Waste Management Act to allow hospitals and other  
          healthcare facilities to accept home-generated sharps waste  
          for consolidation with their own medical waste, and to  
          provide for the establishment of "home-generated sharps  
          consolidation points" such as pharmacies, fire stations,  
          and other facilities where home-generated sharps may be  
          collected.

          SB 1362 (Figueroa), Chapter 157, Statues of 2004, allows  
          city and county household hazardous waste programs to  
          operate as home-generated sharps consolidation points. 

          SB 1305 (Figueroa), Chapter 64, Statutes of 2006, effective  
          September 1, 2008, prohibits any person from knowingly  
          placing home-generated sharps in residential, commercial or  
          construction site waste streams, and requires such wastes  
          to be transported in approved sharps containers and managed  
          at approved sites and facilities, or through approved  
          mail-back programs.  Excludes home-generated sharps waste  
          from the definition of medical waste under the Medical  
          Waste Act, making it a separate type of waste under the  
          Act.

          Arguments in support
          Alameda County, one of the sponsors of AB 501, writes that  
          one million people in California must self-inject  
          prescription medications.  Without a convenient mechanism  
          to safely dispose of sharps, many are disposed of in trash  
          and recycling bins, a practice which jeopardizes the health  
          and safety of workers and potentially increases exposure to  
          diseases such as hepatitis C and HIV/AIDS.

          The California Nurses Association (CNA) states that the use  
          of pre-filled syringes, pens, and devices is an effective  
          method of administering injectible prescription drugs and  
          is expected to increase significantly in the future.   
          However, this increase will be associated with increased  
          disposal problems.  CNA states that sharps mail-back  




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          programs offer one of the most convenient means of  
          collecting and destroying home-generated sharps, and that  
          expanding use of these programs requires greater  
          involvement of the pharmaceutical industry.  

          Taking a support if amended position, the California  
          Association of Environmental Health Administrators (CAEHA)  
          states that AB 501 would require manufacturers to provide  
          sharps containers only upon request from consumers, with no  
          requirement that manufacturers or retailers inform  
          consumers that it is illegal to place the sharps in their  
          household trash.  CAEHA states that local governments are  
          expected to implement a ban on disposal of home-generated  
          sharps starting in September 2008, with no additional  
          resources for education, outreach, or program  
          implementation and that it is unreasonable to expect them  
          to do so without also creating incentives for manufacturers  
          to reduce the amount of waste and costs that local  
          governments must incur.  CAEHA requests amendments to  
          ensure that producers and distributors of sharps are fully  
          responsible for the safe disposal of their products.   
          Taking a similar support if amended position on an earlier  
          version of the bill, the Regional Council of Rural Counties  
          states that it supports amendments to remove the "upon  
          request" provisions of the bill and to impose on the  
          manufacturer an unequivocal requirement to take back used  
          sharps through an automatic postage prepaid mail-back  
          program, rather than allowing them to direct consumers to  
          local disposal options.

          Arguments in opposition
          Sanofi-aventis states that, effective September 1, 2008,  
          current law already requires consumers to properly dispose  
          of needles, including those covered by AB 501, and provides  
          consumers with different methods of safely disposing of  
          home-generated sharps.  Sanofi-aventis states that the duty  
          to ensure safe disposal rests with the consumer and that it  
          is unlikely that those who choose not to comply with the  
          law will change their behavior due to another law on the  
          books.  Sanofi-aventis argues that patients who are  
          prescribed pre-filled syringes or pens are generally  
          educated on the safe use and disposal of these products by  
          health care professionals, and that product inserts for its  
          products state that used needles should be placed in an  
          appropriate sharps container.  To add a requirement that it  




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          also provide a container on request is overly burdensome.   
          Sanofi-aventis also states that the bill excludes certain  
          devices that require needles, but are not sold with  
          needles, and that a more consistent approach would be to  
          exclude manufacturers of products that are sold without  
          needles from the bill.  Sanofi-aventis also argues that the  
          bill does not address the disposal of regular syringes with  
          needles that are dispensed to administer medications that  
          come in vials.

          Amgen states that the bill does not recognize the  
          difference between products intended to be injected at home  
          and products intended to be injected in a medical setting,  
          such as a doctor's office.  Because the distinction is not  
          clear in the bill, many of Amgen's products would be  
          subject to the bill, even though they are not intended to  
          be used at home.


                              COMMENTS AND QUESTIONS
           
          1.  Assembly amendments reduce reliance on pre-paid  
          mail-back containers.  As introduced, AB 501 would have  
          required a pharmaceutical company whose product is  
          dispensed in the form of a pre-filled syringe, pre-filled  
          pen, or other pre-filled injection device to make  
          available, at no cost and through an annually renewable  
          program, postage prepaid, mail-back sharps containers.   
          Under this approach, most sharps would be sent to an  
          approved hazardous waste facility in mail-back containers,  
          with the manufacturer bearing the cost of the container and  
          postage.  Amendments taken in the Assembly allow  
          manufacturers to arrange to provide either a postage  
          prepaid mail-back container or other approved sharps  
          container, which the consumer would be required to  
          transport to an approved collection or consolidation  
          location.  The bill does not require that the latter be  
          provided at no cost to the consumer.  These changes are  
          likely to increase reliance on local hazardous waste  
          collection programs, as well as to require greater efforts  
          on the part of consumers to ensure the safe disposal of  
          home-generated sharps.  

          2.  Scope of bill limited to pre-filled devices.  As  
          introduced, and as currently drafted, AB 501 would apply  




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          only to pre-filled syringes, pens, or other devices, which  
          account for one-third of injectable medications designed or  
          provided for self-administration.  Other types of devices  
          meeting the definition of home-generated sharps waste, such  
          as regular syringes and hypodermic needles, would be  
          excluded.  The author should be asked his reasoning for  
          limiting the scope of the bill to pre-filled syringes,  
          pens, and devices.  

          3.  Information about safe disposal options.  While the  
          bill requires manufacturers of pre-filled devices to  
          provide information on safe disposal alternatives and  
          options, the bill does not specify how they must do that.   
          Additionally, the bill does not include in the information  
          to be provided to consumers notice that state law  
          prohibits, effective September 1, 2008, consumers from  
          disposing of home-generated sharps in conventional waste  
          streams.  Suggested amendments would be to require  
          manufacturers of devices that are subject to the bill to  
          provide information on safe disposal options with the  
          device at the time the device is dispensed to the patient,  
          and to include notice of the prohibition of disposal in  
          containers used for residential or commercial collection of  
          solid waste, recyclable materials, or green waste.
          


          Suggested amendment language:

          On page 3, lines 17 - 20:
          
             (b) In addition to providing an appropriate sharps  
          container, the manufacturer shall provide information on  
          safe disposal alternatives and options for sharps, and  
          notice to the consumer that, effective September 1, 2008,  
          California law prohibits disposal of sharps in any  
          container used for the residential or commercial collection  
          of solid waste, recyclable materials, or green waste.  This  
          information shall be contained in a notice which is  
          prominently displayed and is easily readable, and which is  
          on, or is contained with, the device, at the time it is  
          dispensed.
          
          4.  Manufacturers' requirements and privacy concerns.  The  
          bill requires manufacturers of pre-filled devices to  




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          arrange to provide consumers, upon request, with postage  
          prepaid mail-back sharps containers, or other approved  
          sharps containers.  The author's intent is to allow  
          manufacturers to choose how to meet these requirements, and  
          the author believes that different manufacturers will  
          utilize different options: automatically arranging for  
          containers either to be provided or to be sent to the  
          patient, or providing toll-free numbers or websites with  
          the devices, which consumers can contact to be connected to  
          suppliers of containers and mail-back programs.  However,  
          the language of the bill would allow manufacturers to do  
          less than this, for example, simply handle inquiries  
          through their general customer service number.  In  
          addition, the bill does not preclude manufacturers from  
          obtaining confidential medical information in the process  
          of meeting the bill's requirements, and does not require  
          third parties, with whom the manufacturer contracts in  
          order to meet the requirements of the bill, to be subject  
          to medical privacy laws.  Suggested amendments would be to  
          specify how manufacturers may meet the requirements, and to  
          preclude use of consumers' information for purposes  
          unrelated to providing containers.

          Suggested amendment language:
          
          On page 3, insert a new subdivision (d), as follows:

          (d) (1) A manufacturer may satisfy its obligations under  
          (a) by arranging to provide and paying for a sharps  
          container that meets the requirements of (a) (1) or (a)  
          (2), or supplying a coupon that may be exchanged for a  
          sharps container that meets the requirements of (a) (1) or  
          (a) (2), which would either be delivered to the patient, or  
          included with the device at the time it is dispensed to a  
          patient or prescribed to the   patient, or by providing a  
          toll-free number or website, which is noted on the  
          packaging containing the device, which directs the patient  
          to a supplier of sharps containers that meet the  
          requirements of (a) (1) or (a) (2).  
          (2)  A manufacturer may not use or disclose any medical  
          information, as defined in Section 56.05 of the Civil Code,  
          that it receives in the course of meeting its requirements  
          under this section for any purposes unrelated to meeting  
          the requirements of the section, including for the purposes  
          of marketing, without the written consent of the consumer.   




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          This shall apply to any person or agent with which the  
          manufacturer contracts or otherwise makes arrangements to  
          carry out the requirements of this section.

          
                                         
                                 PRIOR ACTIONS

           Assembly Floor:     45-27
          Assembly Health:    9-6



                                    POSITIONS  
                                        
          Support:   Alameda County Board of Supervisors (sponsor)
                     California Association of Sanitation Agencies
                            California Conference of Machinists
                 California Labor Federation 
                 California Nurses Association
                 County of Santa Clara Board of Supervisors
                 Del Norte Solid Waste Management Authority
                 Engineers and Scientists of California
                 Los Angeles County Solid Waste Management Committee
                 National Multiple Sclerosis Society-California  
          Action Network
                 Planning and Conservation League
                 Regional Council of Rural Counties
                 San Mateo County Central Labor Council
                 Solid Waste Association of North America (SWANA)
                 United Food and Commercial Workers Union, Western  
          States Council


          Oppose:   Amgen
                           Sanofi-aventis




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