BILL ANALYSIS                                                                                                                                                                                                    Ó






                           SENATE COMMITTEE ON HEALTH
                       Senator Ed Hernandez, O.D., Chair

          BILL NO:       SB 315
          AUTHOR:        Wright
          INTRODUCED:    February 14, 2011
          HEARING DATE:  January 11, 2012
          CONSULTANT:    Chan-Sawin

          SUBJECT  :  Ephedrine and pseudoephedrine.

           SUMMARY  :  Eliminates over-the-counter (OTC) sales of 
          products containing ephedrine (EPH), pseudoephedrine (PSE), 
          norpseudoephedrine and phenylpropanolamine; and instead 
          requires the sale or distribution of such products to be 
          made pursuant to prescription only.  Creates an exemption 
          for pediatric liquids containing such drugs from the 
          prescription requirement.  Provides that any person who 
          obtains such products, unless upon prescription of a 
          physician, dentist, podiatrist, or veterinarian licensed by 
          the state, is guilty of an infraction or a misdemeanor.

          Existing federal law:  Establishes the Combat 
          Methamphetamine Epidemic Act of 2005 (CMEA), which includes 
          detailed restrictions and requirements for retail sale of 
          EPH, PSE, norpseudoephedrine or phenylpropanolamine, 
          including:
                 A retailer may sell no more than 3.6 grams in a 
               single transaction;
                 A retailer may sell no more than 7.5 grams per 
               customer in a one-month period;
                 Products containing EPH/PSE shall be kept behind 
               the counter, and sold only after an appropriate form 
               of identification is provided by the purchaser;
                 The seller must maintain a written or electronic 
               logbook of each sale, including the transaction date, 
               the name and address of the purchaser and the quantity 
               sold; and
                 The purchaser must sign a paper or electronic 
               logbook, as specified.
          
          Existing state law:
          1.Defines a "dangerous drug" as one that is unsafe for 
            self-use, including any drug that under federal or state 
            law must be obtained by a prescription, and classifies 
            such controlled substances into five schedules.  A 
                                                         Continued---



                                                       SB 315 | Page 
          2


          

            controlled substance may be possessed or dispensed only 
            through prescriptions, as specified.

          2.Provides the following restrictions and requirements for 
            the sale of EPH, PSE, norpseudoephedrine or 
            phenylpropanolamine in OTC retail transactions, which 
            differ from the federal requirements:
                     A retailer in a single transaction may sell no 
                 more than three packages of a product containing 
                 these chemicals;
                     A retailer may sell no more than nine grams of 
                 EPH, PSE, norpseudoephedrine or phenylpropanolamine 
                 per customer in a one month period;
                     A first violation of these restrictions is a 
                 misdemeanor, punishable by a jail term of up to six 
                 months, a fine of up to $1,000, or both; and
                     A second or subsequent violation is a 
                 misdemeanor, punishable by a jail term of up to one 
                 year, a fine of up to $10,000, or both.

          1.Requires any manufacturer, wholesaler, retailer, or any 
            other person or entity in this state that sells, 
            transfers, or otherwise furnishes OTC drugs containing 
            EPH, PSE, norpseudoephedrine or phenylpropanolamine to a 
            person or business entity in this state or any other 
            state, or who obtains from a source outside of the state 
            any such substances to submit an application to, obtain a 
            permit for, and submit reports on the conduct of such 
            business from the Department of Justice (DOJ).  
          
          2.Defines "pediatric liquid" to mean a nonencapsulated 
            liquid whose unit measure, according to product labeling, 
            is stated in milligrams, ounces, or other similar measure 
            and the dosage unit does not exceed 15 milligrams of 
            phenylpropanolamine or PSE per five milliliters of liquid 
            product, with certain exceptions.

          This bill:
          1.Requires the sale or distribution of EPH, PSE, 
            norpseudoephedrine and phenylpropanolamine to be made by 
            prescription only, and eliminates statutory provisions 
            controlling OTC sale of such products.

          2.Creates an exemption from prescription requirements for 
            pediatric liquids containing such drugs, as defined.




                                                       SB 315 | Page 
          3


          


          3.Makes any person who obtains EPH/PSE or related products, 
            unless upon prescription of a physician, dentist, 
            podiatrist, or veterinarian licensed by the state, guilty 
            of an infraction or a misdemeanor.

           FISCAL EFFECT  :  This bill has not been analyzed by a fiscal 
          committee.

           COMMENTS  :  
           1.Author's statement.  According to the author, 
            methamphetamine (meth) labs pose a serious threat to 
            public safety and the problem is getting worse.  PSE is 
            the essential precursor being used to fuel California and 
            the rest of the nation's meth labs. Oregon and 
            Mississippi have passed similar legislation and both 
            states have significantly reduced meth labs seizures (95% 
            reduction in Oregon and 70% reduction in Mississippi).  
            There have been no negative consequences in either Oregon 
            or Mississippi: no public outcry; the cost of PSE has not 
            increased; health coverage costs have not increased; 
            doctors have not seen an appreciable increase in office 
            visits - including emergency departments; and the 
            uninsured have not been adversely impacted.  PSE is 
            contraindicated for several prevalent ailments (heart 
            disease, liver disease, and hypertension).  According to 
            the PSE manufacturers' warning label, after using PSE for 
            seven days, if symptoms persist, patients should consult 
            with a doctor.  Returning PSE to its prescription status 
            that existed prior to 1976 will save lives (especially 
            young children who do not have the choice of living with 
            meth labs) and save California millions of dollars.

          2.PSE and related compounds in OTC decongestants.  PSE and 
            related compounds, such as EPH, are active ingredients 
            found in many OTC products used to relieve nasal or sinus 
            congestion caused by the common cold, sinusitis, and 
            respiratory allergies.  A prescription is not required in 
            California for such medications sold in retail settings 
            behind the counter, where they are readily available to 
            people without medical insurance or non-emergency access 
            to physicians.  

            Unlike EPH or PSE, phenylephrine cannot be easily 
            converted to meth.  Until 2004, PSE was the most common 




                                                       SB 315 | Page 
          4


          

            active ingredient in decongestant products in the United 
            States.  In recent years, many manufacturers have 
            reformulated their decongestant products to use 
            phenylephrine to avoid restrictions on sales, and 
            phenylephrine is now the most commonly sold decongestant 
            in oral form, nasal sprays, and eye drops.  

            The federal Food and Drug Administration (FDA) approved 
            both phenylephrine and PSE for nasal congestion in 1976, 
            and both are "Generally Recognized as Safe and 
            Effective."  The FDA notes, however, that PSE and 
            phenylephrine differ in duration of action, and 
            recommends that PSE be dosed every 4 to 6 hours, while 
            phenylephrine, which has a shorter duration of action, be 
            dosed every 4 hours.  Thus, while the FDA considers both 
            to be safe and effective for certain intended uses, 
            phenylephrine users must take more of the medication more 
            frequently.

            A statement released by the FDA Office of National Drug 
            Control Policy Director Gil Kerlikowske in testimony 
            before the U.S. Senate at the hearing on "The Status of 
            Meth: Oregon's Experience Making PSE Prescription Only" 
            dated April 19, 2010:

               Any additional measures restricting the sale of PSE to 
               reduce the likelihood of product misuse must be 
               balanced with the need to maintain access for 
               legitimate and safe use.  Requiring an allergy or cold 
               sufferer to obtain a prescription may make it more 
               difficult to access safe and effective products that 
               are intended, when used properly, to treat symptoms 
               that can be self-diagnosed by a consumer.  Individuals 
               respond differently to medications, some getting more 
               benefit from a specific ingredient than others.  
               Having access to different ingredients without the 
               need for obtaining a prescription from a health care 
               professional allows consumers to obtain medications 
               quickly and will not delay access to symptomatic 
               benefit.  Additional consideration should be given to 
               the idea that requiring a prescription could increase 
               health care costs for those who prefer PSE.

          3.Methamphetamine.  Meth is a psychostimulant drug that 
            impacts the central nervous system, is highly 




                                                       SB 315 | Page 
          5


          

            addictive, and can be synthesized with a basic 
            understanding of chemistry.  A principal ingredient in 
            illegal meth production is PSE, and its related 
            compounds.  The drug has limited medical uses for the 
            treatment of narcolepsy, attention deficit disorders, 
            and obesity; however it is seldom prescribed by 
            doctors.  Although meth can be prescribed by a doctor, 
            its medical uses are limited, and the doses that are 
            prescribed are much lower than those typically used 
            illegally.  According to the National Institute on Drug 
            Abuse (NIDA), the immediate effects of meth include 
            increased activity and decreased appetite.  Long-term 
            abuse has many negative health consequences, including 
            extreme weight loss, severe dental problems, anxiety, 
            confusion, insomnia, mood disturbances, and violent 
            behavior.  Chronic meth abusers can also display a 
            number of psychotic features, including paranoia, 
            visual and auditory hallucinations, and delusions. The 
            psychotic symptoms can last for months or years after 
            meth use has ceased.
            Due to its high potential for abuse, meth is classified 
            as a Schedule II drug and is available only through a 
            prescription that cannot be refilled.  Most of the meth 
            abused in this country comes from foreign or domestic 
            superlabs, although it can also be made in small, 
            illegal laboratories, where its production endangers 
            the people in the labs, neighbors, and the environment. 
             According to the Senate Public Safety Committee 
            analysis, if obtained through legal OTC purchases, it 
            would take 1583 packages (each containing 96 tablets, 
            each tablet containing 30 mg of PSE), purchased through 
            1266 separate transactions, to make 10 pounds of meth.  
            Traditional meth cooking methods create serious risks 
            of explosion, and produce relatively large amounts of 
            waste chemicals that are often dumped illegally.  
            However, a new small-scale process - the "shake and 
            bake" or "one pot" method - has become increasingly 
            popular due to the fact that it is less dangerous than 
            traditional cooking methods and only call for about 200 
            tablets of PSE.  While there is substantial danger that 
            the bottle used under this method could explode, the 
            danger appears to mainly be to the cooker and persons 
            in the immediate vicinity, although one-pot cooking can 
            cause particularly intense fires.  





                                                       SB 315 | Page 
          6


          

          4.Methamphetamine use nationally and in California.  The 
            Drug Abuse Warning Network (DAWN) is a national public 
            health surveillance system that monitors drug-related 
            emergency department (ED) visits in the United States and 
            is a source for monitoring meth use.  Results from the 
            August 2010 DAWN report, also compiled by Substance Abuse 
            and Mental Health Services Administration (SAMHSA), 
            indicate that, in 2004, 8.2 percent (or 132,576 visits) 
            of all ED visits involving drug misuse or abuse were 
            related to meth use.  However, by 2008, only 3.3 percent 
            (or 66,308 visits) of such ED visits involved meth.

            The California Department of Alcohol and Drug Programs 
            (DADP), which monitors publicly funded treatment 
            programs, reported in February 2011 that meth is the top 
            reported primary drug for both men and women admitted to 
            California drug treatment programs. However, for women, 
            the percent of admissions for meth is much higher than it 
            is among men; 39.8 percent versus 30.9 percent, 
            respectively, in state fiscal year (SFY) 2007-08.  DADP 
            also reports that, while admissions to meth treatment 
            programs peaked in SFY 2005-06, they declined to the 
            lowest level in six years in SFY 2007-08.

          5.The federal Combat Methamphetamine Epidemic Act.  In 
            2006, the federal CMEA was enacted to restrict the retail 
            sale of PSE and related products.  The CMEA placed many 
            requirements on retail OTC sales of PSE, including daily 
            sales limits and monthly purchase limits, placement of 
            products out of direct customer access, sales logbooks, 
            customer identification requirements, employee training, 
            and self-certification of regulated sellers.  States have 
            also enacted limits on purchases of pseudoephedrine, 
            imposed point-of-sale restrictions, or enacted 
            pseudoephedrine tracking laws.  Oregon and Mississippi 
            are the only two states that currently require a 
            prescription for pseudoephedrine purchases.

          6.Double referral.  This bill was heard in the Senate 
            Public Safety Committee on April 26, 2011, and passed 
            with a 5-2 vote.

          7.Related legislation.  SB 260 (Wright) makes any person or 
            entity who possesses one-half pound or more of PSE, or a 
            specified related chemical, or one-half pound of a 




                                                       SB 315 | Page 
          7


          

            substance containing PSE or a related chemical, as 
            specified, guilty of a felony, punishable by a prison 
            term of 2, 4, or 6 years and a fine of up to $10,000, 
            unless enhancements apply based on the weight or volume 
            of the substance.  Held in Senate Public Safety 
            Committee.

            AB 1280 (Hill) is an alternative measure designed to 
            limit illicit meth manufacturing and abuse by mandating 
            an electronic tracking system for purchases of PSE.  Any 
            retailer of PSE would be required to participate in the 
            system and enter a purchaser's information into the 
            system.  Attempted purchases beyond the federal monthly 
            limit would trigger a notice to the retailer to not 
            complete the sale.  Law enforcement would have access to 
            the system.  Held in Senate Appropriations Committee on 
            the suspense file.

          8.Prior legislation. AB 1455 (Hill) of 2010 was 
            substantively similar to AB 1280 (Hill), and would have 
            also repealed existing statutory provisions for OTC sales 
            of PSE and related products and replaced them with new 
            sales limits consistent with federal law.  Failed passage 
            in the Senate Judiciary Committee.

            SB 484 (Wright) of 2009 was substantially similar to this 
            bill.  Failed passage in the Assembly Public Safety 
            Committee.
            
            SB 1299 (Speier), Chapter 646, Statutes of 2006, makes it 
            a felony, as specified, to possess specified chemicals 
            that are precursors to meth or PCP when the person in 
            possession has the intent to sell, transfer, or otherwise 
            furnish to another person with the knowledge that they 
            will be used to manufacture meth or PCP.
            
            AB 283 (Koretz) of 2005 would have required that the 
            dispensing, sale, or distribution at retail of any 
            compound, mixture, or preparation containing any 
            detectable quantity of EPH, PSE, or any derivative of EPH 
            or PSE to be subject to specified additional 
            requirements.  AB 283 would have required the retailer to 
            store and display the product in a locked cabinet or as 
            specified, and required the transaction to be made by a 
            retailer or employee of a retailer who meets specified 




                                                       SB 315 | Page 
          8


          

            requirements.  These provisions were amended out of the 
            bill.
            
          9.Support.  The Attorney General (AG), the sponsor of SB 
            315, argues that this measure will make it much more 
            difficult for criminals to obtain EPH and PSE, and cites 
            the enormous impact of meth on human life, public safety 
            and health costs.  The AG states that California leads 
            the nation in the amount of meth seized in the past few 
            years.  In 2008 alone, California seized 119 meth labs, 
            by far the highest total in the Western U.S.; 15 out of 
            17 superlabs seized in the U.S. were located in 
            California.  

            The County Alcohol and Drug Program Administrators 
            Association of California argues that meth continues to 
            be a significant problem in California, and demand and 
            supply data suggest that the meth epidemic is rebounding 
            after several years of decline.  This is due to meth 
            producers and users having found ways around federal 
            anti-meth laws, through alternative production methods 
            and organized smurfing efforts, where producers hire a 
            network of individuals to purchase PSE in legal 
            quantities at multiple locations.  

            The California Narcotic Officers Association and the 
            California Police Chiefs Association argue that, in 
            contrast with the state's failing system, Oregon has 
            shown the way to deal with the meth lab issue in 
            California.  They also point out that, upon enactment of 
            the Oregon law, most Oregonians have simply purchased 
            some of the other cold medications that did not contain 
            EPH or PSE, and those who continued to use EPH products 
            supported passage of the Oregon law.  The State Sheriffs' 
            Association concurs and states that the current statutory 
            system includes no way to limit sales when purchasers buy 
            from multiple retail chains.

            The California State Conference of the National 
            Association for the Advancement of Colored People (NAACP) 
            writes in strong support that this bill addresses a 
            pressing need to minimize the proliferation of meth 
            through the state.  California led the nation by a wide 
            margin in the amount of meth created, trafficked and 
            seized during the last few years.  By limiting the 




                                                       SB 315 | Page 
          9


          

            prevalence of meth, the California State Conference of 
            the NAACP believes the state can reduce the number of 
            drug-related arrests and incarcerations in California 
            that disproportionately affect the African American 
            community.  
            
          10.Opposition.  The California Chamber of Commerce states 
            that SB 315 could increase the cost of health care 
            coverage for everyone by forcing individuals to obtain a 
            prescription for products which are now available without 
            a prescription.  By eliminating reasonable access to PSE, 
            this bill imposes a new cost to health insurers to pay 
            for increased doctor visits to obtain the prescription, 
            as well as paying for the cost of the medication as a 
            prescription.

            The California Retailers Association and the National 
            Association of Chain Drug Stores concur and point out 
            this will result in unnecessary delay of treatment for 
            patients, increased costs for employers due to lost 
            employee time, and increased costs to the health care 
            system as the number of visits to the doctor's offices 
            rises.  Patients who do not have health insurance will 
            have to pay out-of-pocket for doctor visits.  
            Alternatively, those who cannot afford to see a physician 
            may be forced to seek care from an emergency department, 
            increasing the burdens on the emergency system and 
            further raising health care costs.

            The California Grocers Association (CGA) states that the 
            bill could have unintended consequences that are 
            significantly detrimental to California's already 
            struggling economy.  Shifting PSE products to 
            prescription-only status will significantly decrease 
            sales tax revenues for state and local governments as 
            California's sales tax does not apply to prescription 
            medications.  CGA argues that the shift will also 
            significantly increase costs to Medi-Cal by forcing 
            participants to use a physician visit to obtain relief 
            from what are generally considered to be relatively minor 
            medical conditions.  Medi-Cal will also be required to 
            pay for this new category of prescriptions at a time when 
            reimbursement rates for both physicians and pharmacies 
            are being reduced and the program is undergoing 
            significant funding cuts.  CGA further points out that 




                                                       SB 315 | Page 
          10


          

            Mexico has already shifted PSE to prescription-only 
            status and yet the country remains the leading source of 
            meth for the United States.

            The Consumer Healthcare Products Association (CHPA) 
            argues that PSE is a safe and effective active ingredient 
            in leading cold and allergy medicines that provide 
            congestion relief.  CHPA states that an estimated 16 
            million Americans purchase PSE annually, and points to 12 
            states that have enacted laws requiring electronic 
            tracking systems for PSE sales, which unifies the 
            logbooks across stores and prevents criminals from 
            skirting the limits by visiting multiple stores.  CHPA 
            believes that an electronic tracking system strikes the 
            proper balance between preventing illegal diversion while 
            preserving access to needed medications.  

          11.Author's Amendments.  SB 315 was heard in Senate Public 
            Safety where the author agreed to take the following 
            amendments in the Committee on Health:
             a.   Sunset the provisions of this bill in five years.
             b.   Require DOJ to conduct a study as to the 
               effectiveness of the bill in reducing meth labs and 
               incidents, and in reducing meth crimes, to be provided 
               to the Legislature by July 1, 2018.
             c.   Allow minors to obtain and possess PSE by 
               prescription.   

          1.Policy concerns.
             a.   Potential impact on health care access and cost.  
               In a widely cited 2007 survey by the Commonwealth 
               Fund, only 27 percent of adults could easily contact 
               their physician over the telephone, obtain care or 
                                                                 medical advice after hours, and experience timely 
               office visits.  As more Americans become insured and 
               begin accessing coverage through implementation of 
               federal health reform, concerns continue to be raised 
               about the number and availability of providers.  The 
               Association of American Medical Colleges estimates 
               that the nation will face a shortage of approximately 
               21,000 primary care physicians in 2015.  By requiring 
               consumers to seek a prescription for PSE and EPH 
               medications, SB 315 may further limit or deny access 
               to this medication for Californians who do not have 
               ready access to a health care provider.  




                                                       SB 315 | Page 
          11


          

               
               In addition, many health plans and insurers also 
               require patients to pay a co-pay to see a provider for 
               non-preventive services.  The prescription 
               requirements in this bill may increase overall cost to 
               the health care system due to such additional costs 
               for outpatient consultations.

             b.   Medi-Cal implications.  Last year's budget trailer 
               bill, AB 97 (Committee on Budget), Chapter 3, Statutes 
               of 2011, implemented a "soft cap" of seven provider 
               visits per year for Medi-Cal beneficiaries (under both 
               Medi-Cal fee-for-service and managed care).  Any 
               visits exceeding the cap will require certification by 
               the physician, or medical professional under the 
               supervision of a physician, attesting that one or more 
               of certain specified circumstances are applicable.

               According to the Department of Health Care Services, 
               if a Medi-Cal patient does not have a pre-existing 
               relationship with a physician, or if the relationship 
               was not such that the physician felt comfortable 
               calling in a prescription without first seeing the 
               patient, then the patient would need to see the 
               physician for a prescription of a drug containing PSE 
               or EPH.  Any such visits would count towards any 
               limitation on the number of visits allowed under the 
               program.  It is unknown how many Medi-Cal 
               beneficiaries have a pre-existing relationship with a 
               doctor.

             c.   Alternative proposal to limit PSE diversion.  AB 
               1280 (Hill) is an alternative measure introduced last 
               year designed to limit illicit meth manufacturing and 
               abuse by mandating an electronic tracking system for 
               purchases of PSE and EPH drugs.  The following states 
               have electronic tracking of pseudoephedrine sales:  
               Alabama, Arkansas, Florida, Illinois, Iowa, Kansas, 
               Kentucky, Louisiana, Missouri, Oklahoma, South 
               Carolina, and Washington.  Ten of these twelve states 
               use the National Precursor Log Exchange (NPLEx), 
               funded by the manufacturers of pseudoephedrine 
               products, to electronically track pseudoephedrine 
               sales.  If implemented appropriately, this proposal 
               may provide an alternative method that curbs meth labs 




                                                       SB 315 | Page 
          12


          

               in the state without incurring potential barriers to 
               access and additional costs to the system. 
            
           SUPPORT AND OPPOSITION  :
          Support:  Attorney General (sponsor)
                    Allergy & Asthma Network, Mothers of Asthmatics
                    California District Attorneys Association
                    California Narcotic Officers Association
                    California Police Chiefs Association
                    California State Conference of the National 
                         Association for the Advancement of Colored 
                         People
                    California State Sheriffs' Association
                    County Alcohol and Drug Program Administrators 
                         Association of California
                    Los Angeles County District Attorney's Office
                    Mississippi Independent Pharmacies Association
                    Oregon Chapter, American College of Emergency 
                    Physicians
                    Oregon State Pharmacy Association
                    Three individuals
          
          Oppose:   Aging Services of California
                    Alameda Health Consortium
                    Association of California Life and Health 
               Insurance Companies
                    Asthma & Allergy Foundation of America, 
                         California Chapter 
                    Bayer HealthCare
                    BIOCOM
                    California Alliance for Retired Americans
                    California Association of Health Plans
                    California Chamber of Commerce
                    California Grocers Association
                    California Healthcare Institute
                    California Manufacturers & Technology Association
                    California Pharmacists Association
                    California Primary Care Association
                    California Professional Firefighters
                    California Retailers Association
                    Community Clinic Association of Los Angeles 
                    County
                    Consumer Healthcare Products Association
                    Drug Policy Alliance
                    Health Net




                                                       SB 315 | Page 
          13


          

                    Healthy African American Families II
                    Kaiser Permanente
                    Los Angeles Society of Allergy, Asthma & Clinical 
               Immunology, Inc.
                    National Association of Chain Drug Stores
                    Reckitt Benckiser
                    Rite Aid
                    Sanofi
                    Valley Industry and Commerce Association
                    Walgreens
                    Three individuals

                                   -- END --