BILL ANALYSIS                                                                                                                                                                                                    �



                                                                  AB 635
                                                                  Page  1

          Date of Hearing:   April 2, 2013

                           ASSEMBLY COMMITTEE ON JUDICIARY
                                Bob Wieckowski, Chair
                 AB 635 (Ammiano) - As Introduced:  February 20, 2013
           
          SUBJECT  :  DRUG OVERDOSE TREATMENT:  LIABILITY

           KEY ISSUES  :  

          1)SHOULD THE EXISTING PILOT PROGRAM FOR OPIOID ANTAGONIST  
            TREATMENT OF DRUG OVERDOSE, WHICH PROVIDES CONDITIONAL  
            AUTHORITY TO LICENSED HEALTH CARE PROVIDERS TO PRESCRIBE AND  
            DISTRIBUTE AN OPIOID ANTAGONIST WITHOUT CIVIL OR CRIMINAL  
            LIABILITY, BE EXPANDED STATEWIDE AND NO LONGER BE SUBJECT TO A  
            SUNSET DATE?

          2)SHOULD SPECIFIED IMMUNITY FROM CIVIL AND CRIMINAL PENALTIES BE  
            EXTENDED TO A PERSON WHO ACTS WITH REASONABLE CARE AND  
            ADMINISTERS AN OPIOID ANTAGONIST IN AN EMERGENCY TO PREVENT  
            THE POSSIBLE DRUG OVERDOSE OF ANOTHER PERSON?

           FISCAL EFFECT  :  As currently in print this bill is keyed  
          non-fiscal.

                                      SYNOPSIS

          Current law authorizes licensed health care providers to  
          prescribe and distribute opioid antagonists for emergency  
          treatment of drug overdose, if done in conjunction with a local  
          overdose prevention program, without being subject to civil  
          liability or criminal prosecution.  This authority, however, is  
          currently limited to health care providers in only seven  
          counties and is set to expire in 2016, pursuant to a pilot  
          program established by SB 767 of 2007.  This bill, co-sponsored  
          by Harm Reduction Coalition and the California Society of  
          Addiction Medicine, seeks to expand this authority statewide and  
          remove the 2016 sunset date.  These proponents contend that  
          recent SB 767 pilot project data demonstrate that naloxone  
          prescription is safe and effective in preventing fatal overdoses  
          without producing significant adverse events, thus justifying  
          removal of the sunset date and pilot program status.  

          Among other things, this bill would allow health care providers  
          to independently prescribe or issue standing orders for the  








                                                                  AB 635
                                                                  Page  2

          distribution or administration of naloxone, as specified,  
          without requiring such acts to be in conjunction with a local  
          prevention program.  This bill provides that a licensed health  
          care provider who acts with reasonable care shall not be subject  
          to professional review, be found liable in a civil action, or be  
          subject to criminal prosecution for issuing a prescription or  
          standing order if he or she complies with the standards set  
          forth by this bill.  In addition, this bill limits liability for  
          any person who possesses or distributes naloxone if it was done  
          pursuant to a prescription or standing order, and limits  
          liability for a person who administers naloxone if the person  
          acts with reasonable care and only administers the drug to  
          someone who is experiencing or is suspected of experiencing an  
          opioid overdose.  The bill is also supported by the Civil  
          Justice Association, defense attorneys, and public defenders,  
          and has no known opposition.
           
          SUMMARY  :  Revises provisions from the current pilot program  
          authorizing prescription of opioid antagonists for treatment of  
          drug overdose and limiting civil and criminal liability, expands  
          these provisions statewide, and removes the 2016 sunset date.   
          Specifically,  this bill  :   

          1)Permits a licensed health care provider who is authorized by  
            law to prescribe an opioid antagonist, if acting with  
            reasonable care, to prescribe and subsequently dispense or  
            distribute an opioid antagonist to a person at risk of an  
            opioid-related overdose or a family member, friend, or other  
            person in a position to assist a person at risk of an  
            opioid-related overdose.  

          2)Permits the licensed health care provider to issue a standing  
            order for the distribution of an opioid antagonist to a person  
            at risk of an opioid-related overdose, or to a family member,  
            friend, or other person in a position to assist a person at  
            risk of an opioid-related overdose.  

          3)Permits the licensed health care provider to issue a standing  
            order for the administration of an opioid antagonist to a  
            person at risk of an opioid-related overdose, by a family  
            member, friend, or other person in a position to assist the  
            person at risk.

          4)Provides that a licensed health care provider who acts with  
            reasonable care shall not be subject to professional review,  








                                                                  AB 635
                                                                  Page  3

            be found liable in a civil action, or be subject to criminal  
            prosecution for issuing a prescription or standing order.

          5)Provides that any person who possesses or distributes an  
            opioid antagonist pursuant to a prescription or standing  
            order, or any person who acts with reasonable care in  
            administering an opioid antagonist to a person experiencing an  
            overdose, shall not be subject to professional review, be  
            found liable in a civil action, or be subject to criminal  
            prosecution for that act.

          6)Deletes provisions restricting the scope of these provisions  
            to seven pilot counties and establishing a 2016 sunset date,  
            extending these provisions indefinitely and expanding  
            authority for the program statewide.

          7)Deletes the requirement that each local health jurisdiction  
            that operates or registers an opioid overdose prevention and  
            treatment training program must report specified data by  
            January 1, 2015 to the Senate and Assembly Judiciary  
            Committees.

           EXISTING LAW  :  

          1)Defines "opioid overdose prevention and treatment training  
            program" to mean any program operated by a local health  
            jurisdiction or that is registered by a local health  
            jurisdiction to train individuals to prevent, recognize, and  
            respond to an opiate overdose, and that provides, at a  
            minimum, training in all of the following:  (a) The causes of  
            an opiate overdose; (b) Mouth to mouth resuscitation; (c) How  
            to contact appropriate emergency medical services; and (d) How  
            to administer an opioid antagonist.  (Civil Code Section  
            1714.22(a)(2).  Unless otherwise stated, all further  
            references are to that code.)

          2)Provides that a licensed health care provider who is permitted  
            by law to prescribe an opioid antagonist may, if acting with  
            reasonable care, prescribe and subsequently dispense or  
            distribute an opioid antagonist in conjunction with an opioid  
            overdose prevention and treatment training program, without  
            being subject to civil liability or criminal prosecution.  
            Further provides that this immunity shall apply to the  
            licensed health care provider even when the opioid antagonist  
            is administered by and to someone other than the person to  








                                                                  AB 635
                                                                  Page  4

            whom it is prescribed.  (Section 1714.22(b).)

          3)Provides that a person who is not otherwise licensed to  
            administer an opioid antagonist may administer it in an  
            emergency without fee if the person has received specified  
            training information and believes in good faith that the other  
            person is experiencing a drug overdose, and shall not as a  
            result of doing so be subject to civil liability for a  
            violation of any professional licensing statute, or subject to  
            any criminal prosecution arising from or related to the  
            unauthorized practice of medicine or the possession of an  
            opioid antagonist.  (Section 1714.22(c).)

          4)Requires each local health jurisdiction that operates or  
            registers an opioid overdose prevention and treatment training  
            program, by January 1, 2010, to collect, and report specified  
            data to the Senate and Assembly Committees on Judiciary on  
            such programs within the jurisdiction.  (Section 1714.22(d).)

          5)Restricts application of these provisions only to the Counties  
            of Alameda, Fresno, Humboldt, Los Angeles, Mendocino, San  
            Francisco, and Santa Cruz.  (Section 1714.22(e).)

          6)Provides that the pilot authority for opioid antagonist  
            treatment with limited immunity from liability shall remain in  
            effect only until January 1, 2016, and as of that date is  
            repealed, unless a later enacted statute, that is enacted on  
            or before January 1, 2016, deletes or extends that date.   
            (Section 1714.22(f).)

          7)Pursuant to the California Uniform Controlled Substances Act,  
            strictly regulates the distribution of controlled substances  
            within California (Health & Safety Code � 11000 et seq.) and  
            prohibits the prescription, administration, or dispensing of a  
            controlled substance to an addict, except under certain  
            circumstances.  (Health & Safety Code Section 11156; Bus. &  
            Prof. Code Section 2241.)

           COMMENTS  :  Current law authorizes licensed health care providers  
          to prescribe and distribute opioid antagonists for emergency  
          treatment of drug overdose, if done in conjunction with an  
          overdose prevention and treatment training program ("overdose  
          prevention program"), without being subject to civil liability  
          or criminal prosecution.  This authority, however, is currently  
          limited to health care providers in only seven counties and is  








                                                                  AB 635
                                                                  Page  5

          set to expire in 2016.  This bill, co-sponsored by Harm  
          Reduction Coalition and the California Society of Addiction  
          Medicine, seeks to expand this authority statewide and remove  
          the 2016 sunset date.  Among other things, this bill would allow  
          health care providers to independently prescribe or issue  
          standing orders for the distribution or administration of  
          naloxone, as specified, but not necessarily in conjunction with  
          a local overdose prevention program.

           Background on properties of naloxone, a common opioid  
          antagonist :  Opioid antagonists are a group of drugs routinely  
          used in hospitals and in pre-hospital settings (i.e. by  
          paramedics in the field) on patients who are suspected to be  
          overdosing on opioids such as heroin, methadone, or oxycodone.   
          The most common type of opioid antagonist is known as naloxone  
          hydrochloride (or its brand name "Narcan"), and is approved by  
          the federal Food and Drug Administration for the treatment of an  
          opioid overdose.  (Hereafter, this analysis will use the term  
          "naloxone" interchangeably with the term "opioid antagonist.")

          Opioid overdoses are characterized by central nervous system and  
          respiratory depression, leading to coma and death.  Naloxone,  
          like other opioid antagonists, has the ability to counteract  
          depression of the central nervous and respiratory system caused  
          by an opioid overdose.  Naloxone is administered by injection  
          into a vein or muscle, with intravenous injection providing for  
          the fastest action.  Once injected, naloxone takes effect after  
          around two minutes, with effects lasting around 45 minutes,  
          potentially saving the person's life.  A New York Times article  
          published August 21, 2005 ("The Shot That Saves ") noted:

            If given early enough, naloxone can prevent damage to the  
            brain caused by lack of oxygen and leave the victim  
            unharmed. According to research   . . .  at least 75  
            percent of overdose deaths involve multiple drugs, usually  
            mixtures of heroin and other depressants like alcohol.  
            Removing the opioid from the mix with naloxone is often  
            enough to revive victims.  

            Naloxone itself is virtually harmless. Its most common  
            side effects are withdrawal symptoms like nausea,  
            shakiness and agitation in those who are physically  
            dependent on opioids. While uncomfortable, these symptoms  
            are not dangerous. Rarely, seizures can occur, but this  
            risk is far lower than the risk to those who are not  








                                                                  AB 635
                                                                  Page  6

            treated. The drug has no effect on those who haven't taken  
            opioids. 

           History of the SB 767 pilot overdose prevention project in  
          California.   In 2008, the Legislature approved and the Governor  
          signed the Overdose Treatment Liability Act (SB 767  
          (Ridley-Thomas) Ch. 477, Stats. 2007) which established a  
          three-year pilot overdose prevention project. Scheduled to  
          sunset on January 1, 2016, the Act grants limited immunity from  
          civil and criminal penalties to licensed health care providers  
          in seven counties for prescribing, dispensing, or distributing  
          naloxone, when acting with reasonable care and in conjunction  
          with a local opioid overdose prevention and treatment training  
          program.  SB 767 designated the counties of Alameda, Fresno,  
          Humboldt, Los Angeles, Mendocino, San Francisco, and Santa Cruz  
          as pilot counties because they already had existing overdose  
          prevention programs in place through their local syringe access  
          and disposal programs.  In 2010, AB 2145 (Ammiano) extended the  
          sunset to 2016 and extended liability protection to third party  
          administrators of naloxone.

          The Harm Reduction Coalition, a co-sponsor of the bill, reports  
          that it is working with health advocates in Stanislaus, San  
          Joaquin, Sacramento, Sonoma, San Diego, Kern, Santa Clara,  
          Ventura and Orange counties who are either already doing  
          independent naloxone distribution as part of an overdose  
          prevention program, or would like to start, as naloxone  
          distribution is now considered 'best practice' components of  
          high quality overdose treatment programs.  Supporters believe  
          that the current pilot program, limited as it is to only seven  
          counties, should be expanded statewide to better address  
          widespread problems of prescription drug overdose.

           This bill would eliminate the SB 767 pilot project and its  
          associated reporting requirements, extending these provisions  
          statewide with no sunset date.   According to the author and  
          sponsor, additional data reported by participating pilot  
          counties since AB 2145 was enacted in 2010 demonstrates that the  
          project has achieved a high rate of success in preventing  
          overdose, coupled with the near total lack of any adverse events  
          associated with administration of naloxone.  These reported  
          figures include the following:

                 San Francisco: For the 2-year period between January  
               2010 and December 2011, a total of 1135 individuals  








                                                                  AB 635
                                                                  Page  7

               received overdose prevention education and were  
               prescribed a total of 2,270 individual doses of naloxone  
               (2 doses per prescription).  A total of 251 individual  
               doses of naloxone were administered during the 185  
               overdose events reported by trained individuals.  Of  
               these events, 182 (98%) resulted in a successful overdose  
               reversal, and in only three cases was the person  
               experiencing drug overdose not revived after receiving  
               naloxone.  No adverse events were reported outside the  
               normal range of symptoms associated with receiving  
               naloxone.

                 Los Angeles:  In 2011, a total of 199 individuals  
               received overdose prevention education and were  
               prescribed naloxone.  A total of 42 overdose events were  
               reported by trained individuals.  Of these events, 41  
               (98%) resulted in a successful overdose reversal, and in  
               only one case was the person not revived after receiving  
               naloxone.  No adverse events were reported outside the  
               normal range of symptoms associated with receiving  
               naloxone.

                 Alameda County:  In 2011, a total of 226 individuals  
               received overdose prevention education and were prescribed  
               naloxone under the auspices of three separately  
               administrated programs.  A total of 65 overdose events were  
               reported by trained individuals.  Of these events, 64 (98%)  
               resulted in a successful overdose reversal, and in only one  
               case was the person not revived after receiving naloxone.   
               No adverse events were reported outside the normal range of  
               symptoms associated with receiving naloxone.

                 Humboldt:  In 2011, 13 individuals were trained and  
               prescribed naloxone through the local program.  A total of  
               four overdose interventions were reported, and all four  
               resulted in successful revival of the individual receiving  
               naloxone.  No adverse events were reported in those cases.

                 Santa Cruz:  In 2011, 100 individuals were trained and  
               prescribed naloxone through the local program.  A total of  
               10 overdose interventions were reported, and all 10  
               resulted in successful revival of the individual receiving  
               naloxone.  No adverse events were reported in those cases.

                 Programs in Fresno and Mendocino at one time had engaged  








                                                                  AB 635
                                                                  Page  8

               in authorized distribution of naloxone under SB 767, but  
               neither program has had sufficient funding to continue  
               dating back to at least 2010, thus no data was reported.

          In short, proponents of this bill contend that SB 767 pilot  
          project data demonstrate that naloxone prescription is safe and  
          effective in saving lives without producing significant adverse  
          events, thus justifying removal of the sunset date and pilot  
          program status.

           Reasons for liability protection for third parties who  
          administer naloxone.   Supporters contend that because naloxone  
          cannot be self-administered by the person experiencing the  
          overdose, it is wise to extend protection from liability to  
          third parties who are trained to administer naloxone, or else  
          they will simply avoid employing naloxone in an emergency even  
          when it is available.  

          Supporters report that county health workers who operate or who  
          desire to operate a naloxone prescription program report are  
          having difficulty finding health care providers who are  
          comfortable writing prescriptions for a medication that will, by  
          necessity, be administered by a third party, without reasonable  
          liability protection.  Furthermore, supporters assert that even  
          so-called "frontline workers" who have taken overdose prevention  
          trainings, and who often are in close contact with drug users at  
          sites like homeless shelters and drug treatment facilities,  
          nevertheless are reluctant to keep the naloxone close at hand  
          for emergency response, without any legal protection for a third  
          party who administrates naloxone.

           In order to facilitate statewide application, this bill revises  
          the authority of health care providers to prescribe naloxone.    
          For the reasons mentioned above, it is necessary to ensure that  
          naloxone may be distributed not only to a person at risk of an  
          overdose, but to others who are in the best position to  
          intervene and administer naloxone in time to possibly prevent  
          death.  Because naloxone is a prescription medication, a person  
          must be prescribed the drug in order to obtain it.  This bill  
          permits a licensed health care provider to prescribe and  
          subsequently dispense or distribute an opioid antagonist to (1)  
          a person at risk of an opioid-related overdose; or (2) a family  
          member, friend, or other person in a position to assist a person  
          at risk of an opioid-related overdose.  









                                                                  AB 635
                                                                  Page  9

          Under existing law, a licensed health care provider may  
          prescribe naloxone "in conjunction with an opioid overdose  
          prevention and treatment training program."  This bill would  
          strike that requirement and instead permit the health care  
          provider to prescribe the drug as long as he acts with  
          reasonable care and is authorized by law to prescribe an opioid  
          antagonist.  In order for naloxone to be available to  
          potentially save lives outside the seven pilot counties, the  
          author recognizes that its prescription cannot be limited to  
          only those doctors working in conjunction with overdose  
          prevention programs-particularly when such programs do not exist  
          in many counties in the state, often because of lack of  
          financial resources.  

          The author notes that naloxone is: (1) non-addictive and  
          regulated at the same level as prescription ibuprofen; (2) has  
          no effect on a person if opioids are absent in their system; and  
          (3) can be safely administered by minimally trained laypeople,  
          as has been demonstrated by data reported through the SB 767  
          pilot project.  In addition, physicians who prescribe  
          medications already have a professional duty to explain those  
          medications to their patients and families, including  
          indications, use, risks and benefits.  For these reasons, the  
          author contends that naloxone prescriptions need not be limited  
          to only doctors operating in conjunction with a local overdose  
          prevention program.

           Standing orders for naloxone distribution or administration.    
          This bill also authorizes licensed health care providers to  
          issue a standing order for the distribution or the  
          administration of the opioid antagonist to the person at risk,  
          or his family member, friend or other person in assistance.   
          Unlike a prescription, which facilitates direct access of the  
          drug to the person for whose use it is intended, a standing  
          order is a type of physician's order that allows other health  
          care workers to exercise the order when certain predetermined  
          conditions are met.  

          Under this bill, an authorized physician may issue one of two  
          kinds of standing orders.  The first authorizes naloxone to be  
          distributed to a person at risk for overdose, or a family  
          member, friend, or other person in a position to assist in the  
          case of an overdose.  Distribution in this context is a  
          preventive measure to increase the chance that naloxone will be  
          available should an overdose event occur.  The second type of  








                                                                  AB 635
                                                                  Page  10

          standing order under this bill authorizes naloxone to be  
          administered (i.e. injected) to help save the life of a person  
          experiencing or reasonably suspected of experiencing an opioid  
          overdose.
           
          Limitations on liability.   With respect to liability for issuing  
          a prescription or standing order, this bill provides that a  
          licensed health care provider who acts with reasonable care  
                                                   shall not be subject to professional review, be found liable in  
          a civil action, or be subject to criminal prosecution for  
          issuing a prescription or standing order if he or she complies  
          with the standards set forth by this bill.  With respect to  
          liability for possession of naloxone, this bill reasonably  
          limits liability for any person who possesses or distributes  
          naloxone if it was done pursuant to a prescription or standing  
          order.  Finally, with respect to the administration of naloxone,  
          the bill limits civil and criminal liability only if the person  
          administers the drug to someone who is experiencing or is  
          suspected of experiencing an overdose, and who acts with  
          reasonable care.

          By limiting liability for naloxone prescription and use strictly  
          pursuant to a prescription or standing order issued by a  
          licensed health care professional, this bill seeks to encourage  
          and enable more health care providers to prescribe naloxone,  
          where appropriate, to certain patients at risk of opioid  
          overdose-particularly important in light of evidence of a  
          substantial epidemic of prescription drug overdoses.  In  
          addition, the author contends, this bill will remove an obstacle  
          to the creation and expansion of more overdose prevention  
          programs in California.

           REGISTERED SUPPORT / OPPOSITION  :   

           Support 
           
          Harm Reduction Coalition (co-sponsor)
          California Society of Addiction Medicine (co-sponsor)
          California Attorneys for Criminal Justice
          California Opioid Maintenance Providers
          California Public Defenders Association
          Civil Justice Association of California (CJAC)

           Opposition 
           








                                                                  AB 635
                                                                  Page  11

          None on file
           
          Analysis Prepared by  :    Anthony Lew / JUD. / (916) 319-2334