BILL ANALYSIS                                                                                                                                                                                                    �







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        |Hearing Date:April 22, 2013        |Bill No:SB                         |
        |                                   |205                                |
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                      SENATE COMMITTEE ON BUSINESS, PROFESSIONS 
                               AND ECONOMIC DEVELOPMENT
                          Senator Curren D. Price, Jr., Chair
                                           

                         Bill No:        SB 205Author:Corbett
                  As Introduced:     February 8, 2013     Fiscal:Yes

        
        SUBJECT:  Prescription drugs: labeling.

        SUMMARY:  Requires prescription labels to be printed in 12-point sans  
        serif typeface.  

        Existing law:
        
        1) Provides for the practice of pharmacy and the licensing and  
           regulation of pharmacies and pharmacists by the Board of Pharmacy  
           (Board) within the Department of Consumer Affairs (DCA).

        2) Specifies certain requirements regarding the dispensing and  
           furnishing of dangerous drugs and devices, and prohibits a person  
           from furnishing any dangerous drug or device except upon the  
           prescription of a physician, dentist, podiatrist, optometrist,  
           veterinarian or naturopathic doctor.  (BPC � 4059)

        1) Requires that each prescription dispensed by a pharmacist must be  
           in a container complying with state and federal law and correctly  
           labeled as specified, including:  (BPC � 4076)

           a)   Unless otherwise ordered by the prescriber, the manufacturer's  
             trade name of the drug or the generic name and the name of the  
             manufacturer, as specified.

           b)   The directions for the use of the drug.

           c)   The name of the patient or patients.

           d)   The name of the prescriber, as specified.





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           e)   The date of issue.

           f)   The name and address of the pharmacy, and prescription number  
             or other means of identifying the prescription.

           g)   The strength of the drug or drugs dispensed.

           h)   The quantity of the drug or drugs dispensed.

           i)   The expiration date of the effectiveness of the drug  
             dispensed.

           j)   The condition for which the drug was prescribed if requested  
             by the patient and the condition is indicated on the  
             prescription.

           aa)       The physical description of the dispensed medication,  
             including its color, shape, and any identification code that  
             appears on the tablets or capsules.

        2) Requires the Board to promulgate regulations on or before January  
           1, 2011, for a standardized, patient-centered, prescription drug  
           label on all prescription medication dispensed in the state. (BPC �  
           4076.5 (a))
         
        3) Requires the Board to hold public meetings statewide in order to  
           seek information on a standardized label from groups representing  
           consumers, seniors, pharmacists, the practice of pharmacy, other  
           health care professionals, and other interested parties.  (BPC �  
           4076.5 (b))

        4) Requires the Board, when considering the requirements for  
           prescription labels, to consider:  (BPC � 4076.5 (c))

           a)   Medical literacy research.

           b)   Improved directions for use.

           c)   Improved font types and sizes.

           d)   Placement of information that is patient-centered.

           e)   The needs of patients with limited English proficiency.

           f)   The needs of senior citizens.





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           g)   Technology requirements necessary to implement the standards.

        This bill:  Prohibits a pharmacist from dispensing any prescription  
        except in a container that meets the requirements of state and federal  
        law and is correctly labeled in at least a 12-point sans serif  
        typeface with information required under current law.

        FISCAL EFFECT:  Unknown.  This bill is keyed "fiscal" by Legislative  
        Counsel.

        COMMENTS:
        
        1. Purpose.  The  Author  is the sponsor of this bill.  According to the  
           Author, "seniors are having difficulty reading the small print on  
           their prescription labels and, for those who take multiple  
           medications, their inability to read the label puts them in serious  
           danger."  The Author states that among adults 65 years of age or  
           older, 40% take five to nine medications and 18% take ten or more  
           medications and that taking these incorrectly or mixed with other  
           medications can cause adverse drug events that can lead to injury  
           and death.  The Author also notes that The New England Journal of  
           Medicine estimates that between 2007 and 2009, there were more than  
           260,000 emergency room visits for adverse drug events in U.S.  
           adults 65 years of age or older.  Of those, almost 100,000 required  
           emergency hospitalizations, and nearly two-thirds of those  
           hospitalizations were due to unintentional overdoses.     

        2. Background. 

           a)    Medication Errors and Legislative Response.  According to  
             the Journal of the American Medical Association, 46 percent  
             of adults cannot understand the information listed on their  
             prescription drug labels.  Furthermore, the Institute of  
             Medicine of the National Academies, medication errors are  
             among the most common medical errors, harming at least 1.5  
             million people annually and senior citizens are especially  
             vulnerable.  Families USA reports that 90 percent of Medicare  
             patients take medications for chronic conditions with nearly  
             half of them taking five or more medications a day.  Given  
             the large numbers of prescriptions that may be prescribed, it  
             is not easily discernable what the purpose for each of these  
             medications is.  This increases the chances that a patient  
             may take the wrong medication increasing the likelihood of  
             serious injury or death.  






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             SCR 49 (Speier, Resolution Chapter 123, Statutes of 2005)  
             established the Medication Errors Panel (Panel) which  
             published a report in March 2007 entitled, "Prescription for  
             Improving Patient Safety: Addressing Medication Errors."  The  
             report listed six general goals to reduce medication errors.   
             Under each goal were recommendations (12 in all) and methods  
             to accomplish each recommendation.  The Panel report states  
             that "the information that consumers need to know about their  
             medication is often complex and may include unfamiliar  
             language or concepts.  Expecting a consumer to retain all the  
             pertinent knowledge from a brief verbal encounter may not be  
             reasonable in many instances."  Although the Panel did not  
             come to consensus on the most important subset of consumers  
             that are at "high risk" for medication errors, it did  
             acknowledge that there are a variety of factors which may  
             increase an individual's risk for experiencing a medication  
             error.  These include:  i) low health literacy; ii) limited  
             English proficiency; iii) cultural incongruence with  
             healthcare providers; iv) physical, cognitive and/or other  
             impairments that make understanding and/or complying with  
             medication instructions difficult; v) age at either end of  
             the age spectrum (the variability of a medication's response,  
             metabolism and dose increases in children and seniors); 
             vi) multiple medications; vii) multiple prescribers; viii)  
             non-prescription medication use (including herbals, dietary  
             supplements, alcohol, and tobacco); and, 
             ix) medication procurement from more than one pharmacy  
             including mail-order. The Panel did state that these factors  
             must be taken into consideration in the development of any  
             consumer education efforts.  

             One bill was pursued in response to the Panel report.  SB  
             472, The California Patient Medication Safety Act, (Corbett,  
             Chapter 470, Statutes 2007) sought to deal with the lack of  
             uniformity in prescription drug labels throughout the state  
             and the resulting confusion and medication errors that may  
             arise.  Much of the conversation during the SB 472 debate  
             focused on the fact that individual pharmacies design and  
             format their own labels, resulting in a lack of standards  
             across all pharmacies which adversely affects medication  
             users who are elderly, suffer from poor vision, have  
             difficulty reading and understanding instructions on labels  
             or have limited English proficiency. 
             The bill required the Board to promulgate regulations on or  
             before January 1, 2011 that require a standardized,  
             patient-centered, prescription drug label on all prescription  





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             medicine dispensed to patients.  Additionally, the Board was  
             required to report to the Legislature by January 1, 2010, on  
             its progress in implementing these regulations.

             This measure is a follow-up to the Author's SB 472 which  
             created the patient-centered label standard.  
             
           b)    Font Size.  According to information provided by the  
             Author, seniors are having
             difficulty reading the small print on their prescription  
             labels and, for those who take multiple medications, their  
             inability to read the label puts them in serious danger.   
             Among adults 65 years of age or older, 40% take five to nine  
             medications and 18% take ten or more medications.   
             Medications that are taken incorrectly or mixed with other  
             medications can cause adverse drug events that can lead to  
             injury and death.  

             The New England Journal of Medicine estimates that between  
             2007 and 2009, there were more than 260,000 emergency room  
             visits for adverse drug events in U.S. adults 65 years of age  
             or older.  Of those, almost 100,000 required emergency  
             hospitalizations, and nearly two-thirds of those  
             hospitalizations were due to unintentional overdoses.  

             According to a study on The Variability and Quality of  
             Medication Container Labels published in the Archives of  
             Internal Medicine, September 10, 2007, the prescription  
             container label may play an important role in the appropriate  
             administration of prescription medication.  The study  
             identified characteristics of container labels that improve  
             readability and understanding, including larger font,  
             boldfacing and use of white space to emphasize important  
             details.

             The United States Pharmacopeial Convention (USP), a  
             scientific nonprofit organization that sets standards for the  
             identity, strength, quality, and purity of medicines,  
             recommends the use of large font size to improve prescription  
             label readability.  USP states that type smaller than size  
             10-point Times New Roman should not be used on prescription  
             labels, and suggests 12-point Times New Roman or 11-point  
             Arial.

        1. Implementation of a Standardized Prescription Drug Label by the  
           Board of Pharmacy.  California is the first state to require  





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           redesigned prescription container labels to emphasize  
           information most important to consumers - offering an element  
           of safety and consistency since prescription labels are the key  
           source patients' reference for information when taking  
           medications in their homes.  Part of this current requirement  
           also ensures that oral interpreter services are available to  
           limited English speaking patients in pharmacies, to insure such  
           patients have access to information about how to take their  
           medications.

           The Board was charged promulgating regulations that require a  
           standardized, patient-centered prescription drug container  
           label for all prescription drugs dispensed to patients in  
           California.  The Board reported on its efforts in a January  
           2010 report to the Legislature.  The Board established a "SB  
           472 Medication Label Subcommittee" in January of 2008 to  
           conduct public forums and to work with organizations and  
           individuals to develop recommendations to implement the  
           provisions of the law to establish a patient-centered  
           prescription drug label.  In May 2008, the Board developed an  
           open-ended prescription label survey for distribution at public  
           outreach events.  A total of 606 consumers completed the  
           surveys.  

           When asked what to change on the prescription label, the top  
           responses were:

              1.      Print should be larger or darker = 30.1%

              2.      Nothing needs to be changed on the label =24.6%

              3.      Include purpose of drug = 12%

           The Board concluded that most consumers participating in the  
           survey requested larger and bolder type font on prescription  
           labels to increase readability.  Many participants suggested  
           that if a generic drug is provided, the prescription label  
           should state the name of the generic drug name and the  
           brand-name it is generic for.  They also noted that color  
           printing and highlighting on labels brings attention to  
           important information. Some participants suggested that the  
           labels themselves be color-coded to help differentiate between  
           multiple medications and family members.  Many consumers  
           responded that they want to know 'what the drug is for' and  
           suggested that 'purpose of drug' be printed directly on  
           prescription labels. 





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           The Board approved a regulation per the requirements set forth  
           in SB 472 after engaging in a lengthy process.  The Board  
           conducted outreach, hearings and information gathering sessions  
           throughout 2008, to collect data from the public on  
           prescription labels and standards for those labels.  The Board  
           considered testimony and information provided from the public,  
           the pharmaceutical industry, pharmacy professionals and  
           literacy subject matter experts on medical literacy research,  
           improved directions for use, improved font types and sizes, the  
           placement of information that is patient-centered, the needs of  
           patients with limited English proficiency, the needs of senior  
           citizens, and technology requirements necessary to implement  
           the standards developed.  Board members were also provided with  
           research articles on designing patient-centered labels.  In  
           2009, the Board discussed the requirements of the regulation at  
           regularly scheduled meetings.  

           Throughout early 2010, the Board held regulation hearings to  
           adopt the proposed regulation, a new section at Title 16  
           California Code of Regulations Section 1707.5 - "Requirements  
           For Patient-Centered Prescription Container Labels."  The  
           regulation outlines that the following items must be clustered  
           into one area of the label that comprises at least 50 percent  
           of the label, using at least 10-point font using sans serif  
           typeface, listing these items in the following order: 

                     Name of the patient
                 
                     Name of the drug and strength of the drug ("name of  
                the drug" means either the manufacturer's trade name, or  
                the generic name and the name of the manufacturer)

                     Directions for use

                     Purpose or condition, if entered onto the  
                prescription by the prescriber, or otherwise known to the  
                pharmacy, and its inclusion on the label is requested by  
                the patient.  

           The regulation also requires pharmacies to have policies and  
           procedures in place to help patients with limited or no English  
           proficiency, understand the information on the label in the  
           patient's language.  The pharmacy's policies and procedures  
           must be specified in writing, and must include, at minimum, the  
           selected means to identify the patient's language, and to  





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           provide interpretive services in the patient's language.   
           Pharmacies must provide, at minimum, interpretive services in  
           the patient's language, if interpretive services in such  
           language are available, during all hours that the pharmacy is  
           open, either in person by pharmacy staff or by use of a  
           third-party interpretive service available by telephone at or  
           adjacent to the pharmacy counter.  

        1. Related Legislation.  SB 204  (Corbett) of 2013 requires pharmacists  
           to use the translated standard directions for use from the Board of  
           Pharmacy's website when providing patients with translated  
           directions in Spanish, Chinese, Vietnamese, Korean, and Russian on  
           their prescription medication labels.  Requires pharmacists to use  
           certified translation services if they choose to provide  
           translations in languages other than the five provided on the  
           Board's website.  The bill is also up for consideration by the  
           Committee at this hearing.

            AB 396  (Fox) of 2013 requires every prescription to include a  
           legible, clear notice of the condition or purpose for which the  
           drug is prescribed, unless the patient or prescriber requests that  
           this information be omitted.  Requires that every prescription  
           container be correctly labeled to include that information, if  
           indicated on the prescription, unless the patient or prescriber  
           requests that this information be omitted.  The bill is currently  
           pending in the Assembly.  

            AB 1136  (Levine) of 2013 requires a pharmacist to include a written  
           label on the drug container indicating that the drug may impair a  
           person's ability to operate a vehicle or vessel.  This bill is  
           currently pending before the Assembly Committee on Business,  
           Professions and Consumer Protection. 
            
           SB 1390  (Corbett) of 2010 would have repealed the requirement that  
           the Board promulgate regulations requiring a standardized,  
           patient-centered, prescription drug label on all prescription  
           medications dispensed to patients in California on or before  
           January 1, 2011, and instead established statutory requirements for  
           standardized, patient centered prescription drug labels.  The bill  
           failed passage in the Assembly Committee on Business, Professions  
           and Consumer Protection.   

            SB 470  (Corbett, Chapter 590, Statutes of 2009) permitted, if  
           requested by patients, the purpose of the prescribed medication to  
           be listed on prescription drug labels. 






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            SB 472  (Corbett, Chapter 470, Statutes of 2007), the California  
           Patient Medication Safety Act, required the Pharmacy Board to  
           promulgate regulations that require a standardized,  
           patient-centered, prescription drug label on all prescription  
           medication dispensed to patients in California.  Additionally, the  
           Board was required to report to the Legislature by January 1, 2010,  
           on its progress in implementing these regulations. 
            
           AB 1276  (Karnette, 2007) would have required medication prescribers  
           to ask a patient if they wanted the intended use on the  
           prescription label.  The measure failed passage in the Assembly  
           Committee on Business and Professions.
            
           SCR 49  (Speier, 2005) created a panel to study the causes of  
           medication errors and recommend changes in the health care system  
           that reduces errors associated with the delivery of prescription  
           and over the counter medication to consumers.  This resolution  
           required the panel to convene by October 1, 2005, and to submit to  
           the Assembly Committee on Health and the Senate Committee on Health  
           a report on its finding by June 1, 2006.
            
           AB 657  (Karnette, 2005) would have required prescription drug  
           labels to include the intended purpose of the drug, if indicated on  
           the prescription, and required prescribers to ask the patient or  
           the patient's authorized representative, if the patient is either  
           incapacitated or a minor who can not provide informed consent,  
           whether to indicate the intended purpose of the prescription on the  
           label.  The bill was held in this Committee at the request of the  
           Author.
            
           AB 288  (Mountjoy, 2005) would have amended the prescription  
           labeling requirement to include the condition for which the drug is  
           prescribed unless the patient, physician or legal guardian  
           requested that the information be omitted.  The measure was held in  
           the Assembly Committee on Business and Professions at the request  
           of the Author.
            
           AB 2125  (Levine, 2004) would have required a physician and surgeon  
           to indicate the patient's diagnosis on each prescription written,  
           unless directed otherwise by the patient and amended the  
           prescription labeling requirement to require that the condition be  
           included on the label unless otherwise directed by the patient.   
           The bill was held in the Assembly Committee on Business and  
           Professions at the request of the Author.
            
           SB 292  (Speier), Chapter 544, Statutes of 2003, required  





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           prescription labels to include a physical description of the drug,  
           including the color, shape, and any identification code that  
           appears on the tablet or capsule.
            
           AB 2099  (Epple) Chapter 397, Statutes of 1993, required that the  
           condition for which the drug is being prescribed must be included  
           on the label if the patient requests that information on the label.

        2. Arguments in Opposition.  The  California Pharmacists Association   
           (CPhA) is opposed to this measure, citing the reasonable balance  
           that was struck during the Board's exhaustive, collaborative  
           rulemaking process to implement a standardized label and lack of  
           data indicating that the existing regulations are insufficient to  
           protect patients.  CPhA cites a Board report provided at a  
           follow-up Public Education and Communication Committee meeting  
           which detailed consumer complaints about the fact that non-key  
           items on the label, like number of remaining refills, were too  
           crowded on the label making them difficult to read.  CPhA also  
           notes that labels are naturally limited in terms of space to  
           provide information and there is already required information that  
           must occupy 50 percent of the label. 

           The  California Grocers Association  (CGA) is opposed to this  
                                             measure.  CGA states that the typeface settings required by this  
           bill are unworkable in a real world setting.  Current law requires  
           no fewer than 11 discrete pieces of information to be placed on a  
           prescription drug label.  In some situations, where a patient's use  
           instructions are non-standard, more detailed information must be  
           included on the label.  According to CGA, requiring size 12 Sans  
           Serif typeface will force pharmacists to dispense some medications  
           in very large containers to accommodate a label large enough to  
           include all the required information.

        
        SUPPORT AND OPPOSITION:
        
         Support:  

        None on file as of April 16, 2013.

         Opposition:  

        California Pharmacists Association (CPhA)
        California Grocers Association







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        Consultant: Kristin Webb and Sarah Mason