BILL ANALYSIS                                                                                                                                                                                                    



                                                                  AB 830
                                                                  Page  1

          Date of Hearing:   May 13, 2009 

                        ASSEMBLY COMMITTEE ON APPROPRIATIONS
                                Kevin De Leon, Chair

                    AB 830 (Cook) - As Amended:  April 23, 2009  

          Policy Committee:                              Health Vote:19-0

          Urgency:     No                   State Mandated Local Program:  
          Yes    Reimbursable:              No

           SUMMARY  

          This bill deletes current law references to specific drug guides  
          and replaces them with a compendium to be approved by the  
          federal Centers for Medicare and Medicaid (CMS).  

           FISCAL EFFECT  

          No direct fiscal impact for providers and payers to continue to  
          provide treatment and reimbursement for off-label uses of  
          medications, especially medications used in oncology. 

           COMMENTS  

           1)Rationale  . This bill is co-sponsored by the Association of  
            Northern California Oncologists (ANCO) and the Medical  
            Oncology Association of Southern California (MOASC) to conform  
            California code references to changes made by CMS with regard  
            to medically accepted indications for off-label use of various  
            medications. Off-label use refers to clinically indicated uses  
            that are not specifically approved by Federal Drug  
            Administration (FDA). The author and sponsors indicate the  
            current specificity in state law requires periodic statutory  
            updating. This bill reduces the need for future updates. 

           2)Background  . Various compendia, such as the American Medical  
            Association Drug Evaluations or the United States  
            Pharmacopoeia-Drug Information, play a role in medical care  
            when alternative uses for drugs help patients and providers  
            access the newest, most effective drugs when evidence becomes  
            available to support specific off-label indications. Oncology  
            in particular, practiced by the sponsors of this bill, relies  
            heavily on off-label uses for drugs. 








                                                                  AB 830
                                                                  Page  2


          For example, Avastin is a drug that was initially approved by  
            the FDA for the treatment of colon cancer.  Subsequently, the  
            FDA approved this medication for the off-label treatment of  
            breast and lung cancer. If an off-label drug is listed in one  
            of the reference guides recognized by CMS, various payers,  
            including Medi-Cal, Medicare, and health plans and insurers  
            are required to pay for it as a treatment. Additional examples  
            of off-label use include Carmustine, which was initially  
            approved for brain tumor treatment and subsequently approved  
            for skin lymphomas and Aletramine, initially approved for  
            ovarian cancer treatment  and subsequently used to treat lung  
            cancer. 
           
           
           Analysis Prepared by  :    Mary Ader / APPR. / (916) 319-2081