BILL ANALYSIS                                                                                                                                                                                                    



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          Date of Hearing:   June 22, 2010

                            ASSEMBLY COMMITTEE ON HEALTH
                              William W. Monning, Chair
                     SB 961 (Wright) - As Amended:  June 10, 2010

           SENATE VOTE  :   26-6
           
          SUBJECT  :   Health care coverage: cancer treatment.

           SUMMARY  :   Requires a health care service plan contract or  
          health insurance policy (collectively carrier contract or  
          policy) that provides coverage for cancer chemotherapy treatment  
          to establish limits on enrollee out of pocket costs for  
          prescribed, orally administered, nongeneric cancer medication.   
          Specifically,  this bill  :    

          1)Requires a carrier contract or policy issued, amended, or  
            renewed on or after January 1, 2011, that provides coverage  
            for cancer chemotherapy treatment, to provide coverage for  
            prescribed, orally administered, nongeneric cancer medication,  
            used to kill or slow the growth of cancerous cells.

          2)Requires the carrier contract or policy referenced in 1)  
            above, to review the percentage cost share for oral nongeneric  
            cancer medication and intravenous (IV) or injected nongeneric  
            cancer medications and apply the lower of the two as the  
            cost-sharing provision for oral nongeneric cancer medications.

          3)Prohibits a carrier contract or policy from providing an  
            increase in enrollee cost sharing for nongeneric cancer  
            medications to any greater extent than the contract or policy  
            provides for an increase in enrollee cost sharing for other  
            nongeneric covered medications.

          4)Defines "cost share" as copayment, coinsurance, or deductible  
            provisions applicable to coverage for oral, IV, or injected  
            nongeneric cancer medications.

          5)Prohibits the provisions of this bill from being construed to  
            require a carrier contract or policy to provide coverage for  
            any additional medication not otherwise required by law.

          6)Clarifies that provisions of this bill do not prohibit a  
            carrier contract or policy from removing a prescription drug  








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            from its formulary of covered prescription drugs.

          7)Prohibits the provisions of this bill from applying to a  
            carrier contract or policy that does not provide coverage for  
            prescription drugs.

          8)Prohibits the provision of this bill from applying to a health  
            care benefit plan or contract entered into with the Board of  
            Administration of the Public Employees' Retirement System  
            (CalPERS) pursuant to the Public Employees' Medical and  
            Hospital Care Act.

          9)Requires the provisions of this bill to remain in effect only  
            until January 1, 2015, and as of that date are repealed,  
            unless a later enacted statute deletes or extends that date.

           
          EXISTING LAW  :

          1)Provides for the regulation of health plans by the Department  
            of Managed Health Care (DMHC) and regulation of health  
            insurers by the California Department of Insurance (CDI).

          2)Requires health plan contracts and health insurance policies  
            to provide coverage for all generally medically accepted  
            cancer screening tests and requires those plans and policies  
            to also provide coverage for the treatment of breast cancer.

          3)Imposes various requirements on contracts and policies that  
            cover prescription drug benefits, such as a requirement to  
            cover "off-label" uses, as specified, and a requirement to  
            cover previously prescribed drugs, as specified.

          4)Authorizes DMHC to regulate the provision of medically  
            necessary prescription drug benefits by a health plan to the  
            extent that the plan provides coverage for those benefits.   
            Existing regulation requires health plans providing outpatient  
            prescription drugs to provide all medically necessary  
            prescription drugs, except as specified in that regulation.

           FISCAL EFFECT  :  According to the Senate Appropriations  
          Committee, pursuant to Senate Rule 28.8, negligible costs.

           COMMENTS  :    









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           1)PURPOSE OF THIS BILL  .  According to the author, the emergence  
            of safe, clinically effective, orally administered anticancer  
            medication has significantly increased the treatment options  
            for cancer patients; however, many barriers currently impede  
            the adoption of orally administered treatment as the main form  
            of cancer therapy.  The author maintains that one of the most  
            significant barriers is greater patient out-of-pocket costs  
            for oral therapies covered under the pharmacy benefit than IV  
            therapies covered under the medical benefit.  The author  
            further maintains that, where IV administered anticancer  
            medications are typically covered under a plan's medical  
            benefit, most patients are only responsible for an office  
            co-payment for each episode of care and are not required to  
            pay a separate fee for the IV drug.  The author argues that,  
            in contrast, orally administered anticancer medications are  
            typically covered under a plan's pharmacy benefit, where many  
            of these agents are placed on a 4th or specialty tier of a  
            prescription plan's formulary.  The author points out that,  
            according to the Kaiser Family Foundation, the average  
            coinsurance rate for 4th tier drugs is 28%, which, for a  
            $3,000 per month oral anticancer medication, could expose a  
            patient to $900 in out-of-pocket spending.  The author  
            believes that this disparity is likely to affect increasing  
            numbers of cancer patients, because 25% of 400 chemotherapy  
            drugs in the development pipeline are oral.

          The author additionally points out that, in 2007, the Oregon  
            State Senate passed similar legislation (S.B. 8 (Courtney),  
            Chapter 566, 2007 Laws), and that, upon enactment of S.B. 8 in  
            January 2008, the top state plans eliminated their high  
            coinsurance rates.  Most Oregon plans established separate  
            oral anticancer therapy coverage under their pharmacy benefit,  
            and patients with no pharmacy benefits gained access to oral  
            anticancer agents through their medical benefit.  The author  
            further notes that, Colorado, Hawaii, Indiana, Iowa, Kansas,  
            Minnesota, Vermont, Washington D.C., and Connecticut have all  
            passed similar legislation. 
           2)CALIFORNIA HEALTH BENEFITS REVIEW PROGRAM  .  AB 1996 (Thomson),  
            Chapter 795, Statutes of 2002, requests the University of  
            California to assess legislation proposing a mandated benefit  
            or service, and prepare a written analysis with relevant data  
            on the medical, economic, and public health impacts of  
            proposed health plan and health insurance benefit mandate  
            legislation.  The California Health Benefits Review Program  
            (CHBRP) was created in response to AB 1996 and extended for  








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            four additional years in SB 1704 (Kuehl), Chapter 684,  
            Statutes of 2006.  

          The June 10, 2010 amendments of this bill reflect similar  
            language expressed in SB 161 (Wright) of 2009 which was  
            analyzed by CHBRP.  Pursuant to a letter from CHBRP dated, Jun  
            17, 2010, the 2009 analysis of SB 161would apply to the  
            current version of this bill.  In its 2009 analysis of SB 161,  
            CHBRP reports the following findings:

              a)   Overview of Oral Anti-Cancer Medications  .  CHBRP reports  
               that, nearly one in two Californians born today will  
               develop cancer at some point in their lifetime.  There are  
               an estimated 140,000 cases of cancer diagnosed each year,  
               while approximately 1.2 million Californians alive today  
               have a history with the disease.  According to CHBRP,  
               breast cancer is the most prevalent cancer in California.   
               Sixty-five percent of the prescriptions and 33% of the  
               total cost for oral anticancer medications are for drugs  
               used to treat breast cancer.  After breast cancer, the next  
               three most common cancers in California are colorectal,  
               prostate, and lung cancer.  Non-Hispanic blacks in  
               California have higher rates of diagnoses of these three  
               cancers compared to all other racial and ethnic groups.   
               These three cancers are all treated using oral anticancer  
               medications; therefore, to the extent that this bill  
               reduces out-of-pocket costs for oral anticancer  
               medications, non-Hispanic black cancer patients could face  
               a reduced financial burden.

             According to CHBRP, oral anticancer medications are used  
               alone or in combination with other oral, IV, or injected  
               anticancer medications, depending on the cancer they are  
               being used to treat.  For many oral anticancer medications,  
               there are no IV or injected substitutes (and vice versa);  
               there are, however, some important exceptions.  Generally,  
               the manner in which anticancer medications are administered  
               depends upon the specific medicine.

             CHBRP states, the most frequently prescribed oral anticancer  
               medications in California in 2006 were three hormone drugs  
               used to treat breast, ovarian, endometrial, and uterine  
               cancers.  The most expensive oral anticancer medications  
               prescribed to Californians are Revlimid (for multiple  
               myeloma and myelodysplastic syndromes), Sutent (for  








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               gastrointestinal stromal tumors and for kidney, renal cell,  
               and thyroid cancers), and Nexavar (for hepatocellular,  
               kidney, renal cell, and thyroid cancers). 

             CHBRP maintains that oral anticancer medications are being  
               prescribed more frequently for cancer treatment.  Four of  
               the five most prevalent cancers in California, including  
               breast, colorectal, prostate, and lung cancers, can be  
               treated using oral anticancer medications.  To date the  
               federal Food and Drug Administration has approved 38 oral  
               anticancer medications used to treat 52 different types of  
               cancer.  According to the National Comprehensive Cancer  
               Network, experts estimate that 400 anticancer medications  
               are currently under development and an estimated 25% of  
               anticancer agents currently in development are oral  
               anticancer treatments.  

             When compared to IV and injectable anticancer medications,  
               oral anticancer medications have both advantages and  
               disadvantages.  According to CHBRP, advantages include that  
               oral anticancer medications may allow administration of the  
               medication on a daily basis; may be more convenient for  
               patients; and, may reduce the risk of infection or other  
               infiltration complications.  Disadvantages include less  
               certainty in patient adherence to treatment regimens and a  
               reduction in interaction between patients and their health  
               care providers to manage complications of treatment. 

              b)   Anticancer Medication Coverage  .  CHBRP reports that  
               coverage for anticancer medications can differ in any of a  
               number of ways, depending on provisions of a person's  
               contract or policy with a carrier.  At a very broad level,  
               anticancer medications may be covered as pharmacy plan  
               benefits or as medical plan benefits, and most plans and  
               insurers depend on the dispensing site to determine which  
               will be the form of coverage.  IV anticancer medication,  
               which is usually provided in a hospital or a physician's  
               office, is generally covered as a medical benefit.  Oral  
               anticancer medications (usually pills) dispensed by a  
               pharmacy are usually covered as a pharmacy benefit.  Some  
               injected anticancer medications are considered  
               "self-injectable," and so are regularly delivered through a  
               pharmacy and covered as a pharmacy benefit.  In part, these  
               variations are due to the fact that pharmacy benefits are  
               relatively new for carrier contracts and policies, having  








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               been added in the 1970s and 1980s, long after  
               hospitalization and physician visits had become covered  
               medical benefits. 

             CHBRP indicates for both medical and pharmacy benefits,  
               payers have devised strategies to promote appropriate  
               utilization and control of costs.  A short list of these  
               strategies includes: creation of formularies; maximization  
               of manufacturer rebates; quantity restrictions; use of  
               prior authorization; development of clinical guidelines;  
               and, implementation of patient cost sharing, such as  
               deductibles, coinsurance, and copayments.  Cost sharing for  
               medications is frequently complicated by tiered pricing.  A  
               carrier may assign drugs to tiers (generic drugs in the  
               lowest and very expensive drugs in the highest) and apply  
               varying copayments and coinsurance rates to different  
               tiers.  As with cost sharing in general, the impact of  
               tiers (if any) depends on the specifics of a person's  
               contract or policy. 

             According to CHBRP, the variety of cost sharing provisions  
               currently used in California makes it difficult to  
               generalize about the ways in which a cancer patient may be  
               required to pay out-of-pocket for any anticancer  
               medication.  Fixed copayments are a common form of cost  
               sharing for medications delivered through a pharmacy.   
               However, some carrier contracts and polices specify  
               coinsurance for one or more medications.  The terms of  
               coverage may or may not include a deductible.  The coverage  
               of medications delivered as medical benefits is equally  
               variable.
               
              c)   Utilization, Cost and Coverage Impacts  .  Based on the  
               results of CHBRP's survey of the six largest plans and  
               insurers, 100% of enrollees are estimated to have at least  
               some coverage for inpatient anticancer medications and  
               outpatient IV and injected anticancer medications, while  
               97.8% of enrollees are estimated to have at least some  
               coverage for outpatient oral anticancer medications.   
               Approximately 472,000 enrollees (2.2%) have no coverage for  
               outpatient oral anticancer medication.  This group includes  
               persons with coverage from small group or individual market  
               policies regulated by CDI. 

             CHBRP states that only 66% of individual market policies  








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               regulated by CDI cover oral anticancer medications, in  
               comparison to 88% of small group policies under CDI.  
               (However, CDI indicates that oral anticancer medication for  
               breast cancer is covered under all CDI products, which  
               CHBRP discounted for this analysis, based on survey  
               results).  One hundred percent of large group policies  
               under CDI covered oral anticancer medications, as did all  
               other market segments.

             CHBRP estimates that 0.5% of people with coverage subject to  
               the mandate will use oral anticancer medications during the  
               year following implementation.  Of the people using  
               anticancer medications, CHBRP estimates that 69.5% use oral  
               only, 20.2% use injected or IV only, and 10.3% use a  
               combination of oral and injected/IV anticancer medications.  


             According to CHBRP, the greatest impact on premiums will be  
               in the small group and individual markets regulated by CDI.  
                While it is possible that this bill will have the  
               unintended consequence of causing small group employers or  
               individuals to drop health care coverage altogether as a  
               result of an increase in premiums, CHBRP projects no  
               measurable impact on the number of persons who are  
               uninsured because the estimated premium increase is 0.025%  
               - which is less than the 1% threshold at which CHBRP would  
               estimate a change in the number of persons covered by  
               insurance.

             CHBRP states that this bill would affect the coverage of more  
               than 21.3 million persons enrolled in group or individual  
               insurance plans or policies in California with anticancer  
               therapy coverage.  CHBRP maintains that it is   expected to  
               increase the premiums paid by both employers and employees  
               (by almost $19.7 million), and would cause a decrease in  
               the out-of-pocket costs paid by members using oral  
               anticancer medications incurred through the cost sharing  
               provisions of a policy or contract (by almost $14.7  
               million).  Total net annual expenditures are estimated to  
               increase by $5 million annually, or 0.0059%, mainly due to  
               administrative costs.

             Of the expected premium increase of about $19,674,000, total  
               premiums for private employers are estimated to increase by  
               $7,287,000, or 0.0144%.  








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             Medi-Cal Managed Care plans and the Healthy Families Program  
               would not be expected to face any expenditure or premium  
               increases because they currently provide oral anticancer  
               medication benefits in accordance with the coverage  
               mandated by this bill.  
             As recently amended, this bill excludes the CalPERS from the  
               provisions of this bill, therefore reducing costs to the  
               state.

             CHBRP reports that approximately 1.6% of the enrollees who  
               use oral anticancer medications have out-of-pocket costs  
               for such medications over $1,000 per year.  Post-mandate  
               amounts shifted from patient to carrier would range from $0  
               to $7,800 per user per year.  The wide variation is related  
               to the price of particular oral anticancer medications and  
               the cost sharing provisions of any one person's contract or  
               policy. 

             According to CHBRP, utilization of oral anticancer  
               medications is not expected to increase as a result of this  
               bill, as 97.8% of enrollees with coverage subject to the  
               mandate already have some coverage for oral anticancer  
               medications, public and private assistance programs exist,  
               price elasticity of demand for anticancer medications is  
               low (as patients will do whatever they can to comply with  
               prescribed treatments, given the life-threatening nature of  
               the illness), and oncologists prescribing behaviors are  
               unlikely to change materially.  Therefore, according to  
               CHBRP, the only potential public health impact as a result  
               of this bill is a reduction in out-of-pocket costs for oral  
               anticancer medications. 

             CHBRP states longer-term impacts on health care costs as a  
               result of the mandate are unknown but are likely to  
               increase over time.  It is estimated that a quarter of  
               chemotherapy treatments in the pipeline are planned as oral  
               medications.  According to a recent pharmaceutical report  
               on cancer medication development, almost 650 new  
               medications and new indications for existing cancer  
               medications are in clinical development.  Several other  
               factors may be influential, such as an increase in the  
               number of patients receiving long-term treatment with more  
               targeted oral anticancer medications, continued growth in  
               the use of combination treatment for various types of  








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               cancers, and expanding indications or off-label use of  
               existing drugs for the treatment of various cancers.

              d)   Administrative Costs  .  According to CHBRP, carrier  
               contract and policies include a component for  
               administration and profit in their premiums.  In estimating  
               the impact of this mandate on premiums, CHBRP states that,  
               actuarial analysis assumes that carriers will apply their  
               existing administration and profit loads to the increase in  
               health care costs produced by this bill.  Therefore, CHBRP  
               indicates, although there may be administrative costs  
               associated with the mandate, administrative costs as a  
               portion of premiums would not change.  In addition, this  
               bill will require that carriers notify members and  
               applicants of their oral chemotherapy coverage changes.   
               Health plans and insurers may also need to increase staff  
               specializing in utilization management.  

           3)FEDERAL HEALTH REFORM  .  On March 23, 2010, President Obama  
            signed the Patient Protection and Affordable Care Act (PPACA);  
            P. L. 111-148, as amended by the Health Care and Education  
            Reconciliation Act of 2010; P. L. 111-152.  PPACA includes  
            prescriptions as a general category that is included in the  
            "essential health benefits package," but at this time it is  
            unclear as to what prescriptions will be covered as an  
            essential benefit.  It is likely that what is covered may  
            remain unknown until federal regulations are promulgated.  The  
            author has included a sunset date of January 1, 2015 for the  
            provisions of this bill, unless a later enacted statute  
            deletes or extends the date, in order to accommodate potential  
            direction from the federal level.  

          4)SUPPORT  .  According to Carrie's TOUCH, Inc. (Carrie's TOUCH),  
            the sponsors of this bill, the emergence of clinically safe  
            and effective, orally administered anticancer medication has  
            significantly increased the treatment options for cancer  
            patients.  Carrie's TOUCH maintains that there is a disparity  
            that exists between the medical and pharmacy benefit design  
            creating greater out-of-pocket responsibilities for oral  
            anticancer treatment covered under the pharmacy benefit than  
            the out of pocket costs for IV treatment covered under the  
            medical benefit.  Carrie's TOUCH argues that the cost barriers  
            currently impede access to orally administered cancer  
            treatment.  The American Cancer Society (ACS) states that  
            patients using oral chemotherapy generally experience milder  








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            side effects and avoid the need for transportation back and  
                               forth to chemotherapy appointments, which, depending on a  
            patient's circumstances can be onerous for the patient and the  
            caretakers.  ACS further states that many oral chemotherapy  
            treatments do not have IV counterparts, making the need to  
            ensure access to them critical.  AstraZeneca argues in support  
            that access to effective medicines, including oral and IV  
            therapies, should be determined by medical appropriateness -  
            as determined by a physician in consultation with a patient.   
            AstraZeneca asserts that ensuring oral chemotherapy agents are  
            covered in a similar manner as intravenous therapies helps to  
            ensure that a physician has all of the necessary tools  
            available to help patients and their family caregivers.  

          5)OPPOSITION  .  The Association of California Life and Health  
            Insurance Companies (ACLHIC), in opposition to this bill  
            states that it will put carriers at a disadvantage during  
            negotiations with pharmaceutical companies regarding drug  
            pricing.  ACLHIC maintains that knowing that health insurers  
            would be mandated to include these oral drugs on their  
            formularies, pharmaceutical companies would lack any incentive  
            to negotiate in good faith.  Blue Shield of California asserts  
            that this bill does not contain a correlating price control on  
            what the pharmaceutical manufacturer can charge a carrier for  
            purchasing the oral anticancer medication.  Blue Shield argues  
            that this means the drug manufacturer can charge whatever  
            price they choose and this bill would limit the carrier's  
            ability to properly fold those costs into their product  
            offerings.  Health Net argues that given the downturn in the  
            economy, many employers are struggling to provide coverage for  
            their employees.  According to Health Net, mandates as  
            expressed in this bill will only make health care coverage  
            more expensive. 

          6)PREVIOUS LEGISLATION  .  SB 161, substantially similar to this  
            bill, would have required a carrier contract or policy that  
            provides coverage for anticancer treatment to provide coverage  
            for a prescribed, orally administered anticancer medication on  
            a basis no less favorable than IV or injected anticancer  
            medications.  SB 161 was vetoed by Governor Arnold  
            Schwarzenegger stating that SB 161 limits a carrier's ability  
            to control both the appropriateness of the care and the cost  
            by requiring them to immediately cover every medication as  
            soon as it receives federal approval, regardless of the  
            provisions of the carrier's formulary, placing carriers at a  








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            severe disadvantage when negotiating prices with drug  
            manufacturers.  The Governor further stated his belief that  
            oral anticancer medications were more cost-effective and  
            efficacious in some instances and encouraged the author, for  
            reconsideration this year, to collaborate with his  
            Administration, carriers, and the pharmaceutical manufacturers  
            to explore whether there were ways to provide greater access  
            without increasing costs.  

          7)POLICY ISSUE  .  From a policy perspective, the provisions to  
            exclude CalPERS appear to be inconsistent with this bill's  
            intent to make oral cancer medications available to all  
            persons with health coverage.  The author may wish to address  
            the rationale for exempting CalPERS from this bill.  

          REGISTERED SUPPORT / OPPOSITION  :

           Support 
           
          Carrie's TOUCH, Inc. (sponsor)
          American Cancer Society
          AstraZeneca
          BayBio
          California Communities United Institute
          California Healthcare Institute
          California Medical Association
          Disability Rights Legal Center
          International Myeloma Foundation 
          Oncology Nursing Society
          The Leukemia & Lymphoma Society
          Susan G. Komen for the Cure
           
            Opposition 
           
          Association of California Life & Health Insurance Companies
          Blue Shield of California
          California Association of Health Plans
          California Chamber of Commerce
          Health Net
          Medco Health Solutions, Inc.

           Analysis Prepared by  :    Tanya Robinson-Taylor / HEALTH / (916)  
          319-2097