BILL ANALYSIS                                                                                                                                                                                                    �



                                                                  AB 1277
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          Date of Hearing:   May 11, 2011

                        ASSEMBLY COMMITTEE ON APPROPRIATIONS
                                Felipe Fuentes, Chair

                    AB 1277 (Hill) - As Amended:  April 13, 2011 

          Policy Committee:                             Business and 
          Professions  Vote:                            9-0
                       Health                           Vote: 17-0

          Urgency:     No                   State Mandated Local Program: 
          No     Reimbursable:              No

           SUMMARY  

          This bill reduces state oversight of drug and device 
          manufacturers in California.  Specifically, this bill:

          1)Clarifies that manufacturers of new biologic products are 
            included in existing law allowing manufacturers of drugs and 
            medical devices to sell, deliver, or give away their products 
            in California if they meet existing licensing and approval 
            requirements prescribed by the federal Food and Drug 
            Administration (FDA).

          2)Changes the frequency of state licensing inspections for these 
            manufacturers from once every two years to once every four 
            years.

          3)Permits DPH to perform follow up inspections, as specified, to 
            protect the health and safety of the public, rather than to 
            determine ownership, adequacy of facilities, personnel 
            qualifications, and compliance with current law. 

          4)States legislative intent to preclude DPH from requiring drug 
            and medical device manufacturers who meet federal requirements 
            to also obtain separate state approval from DPH, except to the 
            extent that DPH requires documentation that the federal 
            requirements are met.
           
          FISCAL EFFECT  

          1)Reduced cost pressure to the Drug and Device Safety special 
            fund within DPH, associated with reduced frequency of 








                                                                  AB 1277
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            inspections.  

          2)It is unclear whether the reduction in inspection frequency 
            will result in decreased expenditures for drug and device 
            regulation, as there is an existing and ongoing backlog in 
            initial licensure inspections.  DPH indicates initial 
            licensure of manufacturers requires significantly more time 
            than renewal inspections, and the number of new manufacturers 
            continues to exceed DPH projections.

           COMMENTS  

           1)Rationale  . According to the author, inspections by DPH are 
            duplicative of inspections by the federal Food and Drug 
            Administration, and place a financial burden on companies that 
            must pay licensing fees and expend substantial financial 
            resources to facilitate these inspections.  This bill intends 
            to limit ease the regulatory burden of having two regulatory 
            entities.

           2)Background  .  DPH's Food and Drug Branch (FDB) is responsible 
            for licensing and inspecting all manufacturers of 
            pharmaceutical drug products, including biologics, and medical 
            devices in California unless the manufacturer is specifically 
            exempted.  DPH currently licenses and inspects 1,673 drug and 
            medical device manufacturing firms in California.  FDB is 
            required to inspect the place of manufacture prior to issuing 
            a new drug or medical device manufacturing license, and every 
            two years thereafter.  Firms cannot legally manufacture in 
            California without a valid license.  

           Analysis Prepared by  :    Lisa Murawski / APPR. / (916) 319-2081