BILL ANALYSIS                                                                                                                                                                                                    �



                                                                            



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                                        VETO


          Bill No:  SB 205
          Author:   Corbett (D)
          Amended:  9/6/13
          Vote:     21


           SENATE BUSINESS, PROF. & ECON. DEVELOP. COMM  :  6-0, 4/22/13
          AYES:  Price, Block, Corbett, Hernandez, Hill, Padilla
          NO VOTE RECORDED:  Emmerson, Galgiani, Wyland, Yee

           SENATE APPROPRIATIONS COMMITTEE  :  5-0, 5/13/13
          AYES:  De Le�n, Hill, Lara, Padilla, Steinberg
          NO VOTE RECORDED:  Walters, Gaines

           SENATE FLOOR  :  23-9, 5/16/13
          AYES:  Beall, Block, Calderon, Corbett, Correa, De Le�n,  
            DeSaulnier, Evans, Hancock, Hernandez, Hill, Hueso, Jackson,  
            Lara, Leno, Lieu, Liu, Padilla, Pavley, Roth, Steinberg, Wolk,  
            Wright
          NOES:  Anderson, Emmerson, Fuller, Gaines, Huff, Knight,  
            Nielsen, Wyland, Yee
          NO VOTE RECORDED:  Berryhill, Cannella, Galgiani, Monning,  
            Price, Walters, Vacancy, Vacancy

           ASSEMBLY FLOOR  :  47-27, 9/10/13 - See last page for vote

           SENATE FLOOR  :  24-12, 9/11/13
          AYES:  Beall, Block, Calderon, Corbett, Correa, De Le�n,  
            DeSaulnier, Evans, Galgiani, Hancock, Hernandez, Hill, Hueso,  
            Jackson, Lara, Leno, Monning, Padilla, Pavley, Roth,  
            Steinberg, Torres, Wolk, Wright
          NOES:  Anderson, Berryhill, Emmerson, Fuller, Gaines, Huff,  
            Knight, Nielsen, Vidak, Walters, Wyland, Yee
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          NO VOTE RECORDED:  Cannella, Lieu, Liu, Vacancy


           SUBJECT  :    Prescription drugs:  labeling

           SOURCE  :     Author


           DIGEST  :    This bill requires certain portions of the required  
          information on prescription labels, including the name of the  
          patient(s), to be printed in at least 12-point sans serif  
          typeface.  

           ANALYSIS  :    

          Existing law:

          1.Requires that each prescription dispensed by a pharmacist must  
            be in a container complying with state and federal law and  
            correctly labeled as specified, including (a) unless otherwise  
            ordered by the prescriber, the manufacturer's trade name of  
            the drug or the generic name and the name of the manufacturer,  
            as specified; (b) the directions for the use of the drug; (c)  
            the name of the patient(s); (d) the name of the prescriber, as  
            specified; (e) the date of issue; (f) the name and address of  
            the pharmacy, and prescription number or other means of  
            identifying the prescription; (g) the strength and quantity of  
            the drug(s) dispensed; (h) the expiration date of the  
            effectiveness of the drug dispensed; (i) the condition for  
            which the drug was prescribed if requested by the patient and  
            the condition is indicated on the prescription; and (j) the  
            physical description of the dispensed medication, including  
            its color, shape, and any identification code that appears on  
            the tablets or capsules.

          2.Requires the Board of Pharmacy (Board) to promulgate  
            regulations on or before January 1, 2011, for a standardized,  
            patient-centered, prescription drug label on all prescription  
            medication dispensed in the state.

          3.Requires the Board to hold public meetings statewide in order  
            to seek information on a standardized label from groups  
            representing consumers, seniors, pharmacists, the practice of  
            pharmacy, other health care professionals, and other  

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            interested parties. 

          4.Requires the Board, when considering the requirements for  
            prescription labels, to consider medical literacy research,  
            improved directions for use, improved font types and sizes,  
            placement of information that is patient-centered, the needs  
            of patients with limited English proficiency, the needs of  
            senior citizens, and technology requirements necessary to  
            implement the standards.

          This bill:

          1.Prohibits, beginning January 1, 2016, a pharmacist from  
            dispensing any prescription except in a container that meets  
            the requirements of state and federal law and is correctly  
            labeled with certain information required under existing law,  
            including the name of the patient(s) and printed in at least  
            12-point typeface.

          2.Adds language to avoid chaptering conflicts with SB 493  
            (Hernandez).

           Background
           
           Medication errors and legislative response  .  According to the  
          Journal of the American Medical Association, 46% of adults  
          cannot understand the information listed on their prescription  
          drug labels.  Furthermore, the Institute of Medicine of the  
          National Academies, medication errors are among the most common  
          medical errors, harming at least 1.5 million people annually and  
          senior citizens are especially vulnerable.  Families USA reports  
          that 90% of Medicare patients take medications for chronic  
          conditions with nearly half of them taking five or more  
          medications a day.  Given the large numbers of prescriptions  
          that may be prescribed, it is not easily discernible what the  
          purpose for each of these medications is.  This increases the  
          chances that a patient may take the wrong medication increasing  
          the likelihood of serious injury or death.

          SCR 49 (Speier, Resolution Chapter 123, Statutes of 2005)  
          established the Medication Errors Panel (Panel) which published  
          a report in March 2007 entitled "Prescription for Improving  
          Patient Safety: Addressing Medication Errors."  The report  
          listed six general goals to reduce medication errors.  Under  

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          each goal were recommendations (12 in all) and methods to  
          accomplish each recommendation.  The Panel report states that  
          "the information that consumers need to know about their  
          medication is often complex and may include unfamiliar language  
          or concepts.  Expecting a consumer to retain all the pertinent  
          knowledge from a brief verbal encounter may not be reasonable in  
          many instances."  The Panel acknowledged that there are a  
          variety of factors which may increase an individual's risk for  
          experiencing a medication error.  These include (1) low health  
          literacy; (2) limited English proficiency; (3) cultural  
          incongruence with healthcare providers; (4) physical, cognitive  
          and/or other impairments that make understanding and/or  
          complying with medication instructions difficult; (5) age at  
          either end of the age spectrum (the variability of a  
          medication's response, metabolism and dose increases in children  
          and seniors); (6) multiple medications; (7) multiple  
          prescribers; (8) non-prescription medication use (including  
          herbals, dietary supplements, alcohol, and tobacco); and (9)  
          medication procurement from more than one pharmacy including  
          mail-order.  The Panel stated that these factors must be taken  
          into consideration in the development of any consumer education  
          efforts.

          One bill was pursued in response to the Panel report - SB 472  
          (Corbett, Chapter 470, Statutes of 2007), the California Patient  
          Medication Safety Act, which sought to deal with the lack of  
          uniformity in prescription drug labels throughout the state and  
          the resulting confusion and medication errors that may arise.   
          Much of the conversation during the SB 472 debate focused on the  
          fact that individual pharmacies design and format their own  
          labels, resulting in a lack of standards across all pharmacies  
          which adversely affects medication users who are elderly, suffer  
          from poor vision, have difficulty reading and understanding  
          instructions on labels or have limited English proficiency.    
          The bill required the Board to promulgate regulations on or  
          before January 1, 2011 that require a standardized,  
          patient-centered, prescription drug label on all prescription  
          medicine dispensed to patients.  Additionally, the Board was  
          required to report to the Legislature by January 1, 2010, on its  
          progress in implementing these regulations.

           Font size  .  According to information provided by the author's  
          office, seniors are having difficulty reading the small print on  
          their prescription labels and, for those who take multiple  

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          medications, their inability to read the label puts them in  
          serious danger.  Among adults 65 years of age or older, 40% take  
          five to nine medications and 18% take 10 or more medications.   
          Medications that are taken incorrectly or mixed with other  
          medications can cause adverse drug events that can lead to  
          injury and death.  

          The New England Journal of Medicine estimates that between 2007  
          and 2009, there were more than 260,000 emergency room visits for  
          adverse drug events in U.S. adults 65 years of age or older.  Of  
          those, almost 100,000 required emergency hospitalizations, and  
          nearly two-thirds of those hospitalizations were due to  
          unintentional overdoses.  

          According to a study on The Variability and Quality of  
          Medication Container Labels published in the Archives of  
          Internal Medicine, September 10, 2007, the prescription  
          container label may play an important role in the appropriate  
          administration of prescription medication.  The study identified  
          characteristics of container labels that improve readability and  
          understanding, including larger font, boldfacing and use of  
          white space to emphasize important details.

          The United States Pharmacopeial Convention (USP), a scientific  
          nonprofit organization that sets standards for the identity,  
          strength, quality, and purity of medicines, recommends the use  
          of large font size to improve prescription label readability.   
          USP states that type smaller than size 10-point Times New Roman  
          should not be used on prescription labels, and suggests 12-point  
          Times New Roman or 11-point Arial.

           Implementation of a standardized prescription drug label by the  
          Board  .  California is the first state to require redesigned  
          prescription container labels to emphasize information most  
          important to consumers - offering an element of safety and  
          consistency since prescription labels are the key source  
          patients' reference for information when taking medications in  
          their homes.  Part of this current requirement also ensures that  
          oral interpreter services are available to limited English  
          speaking patients in pharmacies, to insure such patients have  
          access to information about how to take their medications.

          The Board was charged promulgating regulations that require a  
          standardized, patient-centered prescription drug container label  

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          for all prescription drugs dispensed to patients in California.   
          The Board reported on its efforts in a January 2010 report to  
          the Legislature.  The Board established the "SB 472 Medication  
          Label Subcommittee" in January 2008 to conduct public forums and  
          to work with organizations and individuals to develop  
          recommendations to implement the provisions of the law to  
          establish a patient-centered prescription drug label.  In May  
          2008, the Board developed an open-ended prescription label  
          survey for distribution at public outreach events.  A total of  
          606 consumers completed the surveys.  

          When asked what to change on the prescription label, the top  
          responses were:

           Print should be larger or darker = 30.1%
           Nothing needs to be changed on the label = 24.6%
           Include purpose of drug = 12%

          The Board concluded that most consumers participating in the  
          survey requested larger and bolder type font on prescription  
          labels to increase readability.  Many participants suggested  
          that if a generic drug is provided, the prescription label  
          should state the name of the generic drug name and the  
          brand-name it is generic for.  They also noted that color  
          printing and highlighting on labels brings attention to  
          important information.  Some participants suggested that the  
          labels themselves be color-coded to help differentiate between  
          multiple medications and family members.  Many consumers  
          responded that they want to know 'what the drug is for' and  
          suggested that 'purpose of drug' be printed directly on  
          prescription labels. 

          The Board approved a regulation per the requirements set forth  
          in SB 472 after engaging in a lengthy process.  The Board  
          conducted outreach, hearings and information gathering sessions  
          throughout 2008, to collect data from the public on prescription  
          labels and standards for those labels.  The Board considered  
          testimony and information provided from the public, the  
          pharmaceutical industry, pharmacy professionals and literacy  
          subject matter experts on medical literacy research, improved  
          directions for use, improved font types and sizes, the placement  
          of information that is patient-centered, the needs of patients  
          with limited English proficiency, the needs of senior citizens,  
          and technology requirements necessary to implement the standards  

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          developed.  Board members were also provided with research  
          articles on designing patient-centered labels.  In 2009, the  
          Board discussed the requirements of the regulation at regularly  
          scheduled meetings.  

          Throughout early 2010, the Board held regulation hearings to  
          adopt the proposed regulation, a new section at Title 16  
          California Code of Regulations Section 1707.5 - "Requirements  
          For Patient-Centered Prescription Container Labels."  The  
          regulation outlines that the following items must be clustered  
          into one area of the label that comprises at least 50% of the  
          label, using at least 10-point font using sans serif typeface,  
          listing these items in the following order: (1) name of the  
          patient; (2) name of the drug and strength of the drug ("name of  
          the drug" means either the manufacturer's trade name, or the  
          generic name and the name of the manufacturer); (3) directions  
          for use; and (4) purpose or condition, if entered onto the  
          prescription by the prescriber, or otherwise known to the  
          pharmacy, and its inclusion on the label is requested by the  
          patient.  

          The regulation also requires pharmacies to have policies and  
          procedures in place to help patients with limited or no English  
          proficiency, understand the information on the label in the  
          patient's language.  The pharmacy's policies and procedures must  
          be specified in writing, and must include, at minimum, the  
          selected means to identify the patient's language, and to  
          provide interpretive services in the patient's language.   
          Pharmacies must provide, at minimum, interpretive services in  
          the patient's language, if interpretive services in such  
          language are available, during all hours that the pharmacy is  
          open, either in person by pharmacy staff or by use of a  
          third-party interpretive service available by telephone at or  
          adjacent to the pharmacy counter.  
          
           FISCAL EFFECT  :    Appropriation:  No   Fiscal Com.:  Yes    
          Local:  Yes

          According to the Assembly Appropriations Committee, there are  
          minor and absorbable costs.

           SUPPORT  :   (Verified  9/10/13)

          California Alliance for Retired Americans

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          California Commission on Aging
          California Pan-Ethnic Health Network
          California State Retirees, Chapter 1
          Paramedics Plus
          Pharmacists Planning Services, Inc.
          Visi�n y Compromiso

           OPPOSITION  :    (Verified  9/10/13)

          California Board of Pharmacy
          California Department of Consumer Affairs
          California Department of Finance
          California Grocers Association
          California Pharmacists Association
          National Association of Chain Drug Stores

           ARGUMENTS IN SUPPORT  :    According to the author, "seniors are  
          having difficulty reading the small print on their prescription  
          labels and, for those who take multiple medications, their  
          inability to read the label puts them in serious danger."  The  
          author's office states that among adults 65 years of age or  
          older, 40% take five to nine medications and 18% take ten or  
          more medications and that taking these incorrectly or mixed with  
          other medications can cause adverse drug events that can lead to  
          injury and death.  The author's office also notes that The New  
          England Journal of Medicine estimates that between 2007 and  
          2009, there were more than 260,000 emergency room visits for  
          adverse drug events in U.S. adults 65 years of age or older.  Of  
          those, almost 100,000 required emergency hospitalizations, and  
          nearly two-thirds of those hospitalizations were due to  
          unintentional overdoses.

           ARGUMENTS IN OPPOSITION  :    The California Pharmacists  
          Association (CPhA) cites the reasonable balance that was struck  
          during the Board's exhaustive, collaborative rulemaking process  
          to implement a standardized label and lack of data indicating  
          that the existing regulations are insufficient to protect  
          patients.  CPhA cites a Board report provided at a follow-up  
          Public Education and Communication Committee meeting which  
          detailed consumer complaints about the fact that non-key items  
          on the label, like number of remaining refills, were too crowded  
          on the label making them difficult to read.  CPhA also notes  
          that labels are naturally limited in terms of space to provide  
          information and there is already required information that must  

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          occupy 50% of the label. 
          
          The California Grocers Association (CGA) states that the  
          typeface settings required by this bill are unworkable in a real  
          world setting.  Existing law requires no fewer than 11 discrete  
          pieces of information to be placed on a prescription drug label.  
           In some situations, where a patient's use instructions are  
          non-standard, more detailed information must be included on the  
          label.  According to CGA, requiring size 12-sans serif typeface  
          will force pharmacists to dispense some medications in very  
          large containers to accommodate a label large enough to include  
          all the required information.

           GOVERNOR'S VETO MESSAGE:
           
            "I am returning Senate Bill 205 without my signature. 

            The bill would require certain parts of a prescription drug's  
            label to be printed in at least 12-point typeface. 

            The Board of Pharmacy is required to provide an update of its  
            2010 labeling guidelines to the Legislature next month.  I  
            prefer to wait for their findings before mandating such a  
            change."

          ASSEMBLY FLOOR  :  47-27, 9/10/13
          AYES:  Alejo, Ammiano, Atkins, Bloom, Bocanegra, Bonilla, Bonta,  
            Bradford, Brown, Campos, Chau, Chesbro, Cooley, Dickinson,  
            Eggman, Fong, Fox, Frazier, Garcia, Gomez, Gonzalez, Gordon,  
            Hall, Roger Hern�ndez, Holden, Jones-Sawyer, Levine,  
            Lowenthal, Medina, Mitchell, Mullin, Muratsuchi, Nazarian,  
            Pan, V. Manuel P�rez, Quirk, Quirk-Silva, Rendon, Salas,  
            Skinner, Stone, Ting, Weber, Wieckowski, Williams, Yamada,  
            John A. P�rez
          NOES:  Achadjian, Allen, Bigelow, Ch�vez, Conway, Dahle,  
            Donnelly, Beth Gaines, Gatto, Gorell, Gray, Grove, Hagman,  
            Harkey, Jones, Linder, Logue, Maienschein, Mansoor, Melendez,  
            Morrell, Nestande, Olsen, Patterson, Wagner, Waldron, Wilk
          NO VOTE RECORDED:  Buchanan, Ian Calderon, Daly, Perea, Vacancy,  
            Vacancy

          MW:ndek  1/6/14   Senate Floor Analyses 

                           SUPPORT/OPPOSITION:  SEE ABOVE

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